Protein: TSP1
Thrombospondin-1 (Glycoprotein G)

Gene: TSP1, THBS1
Organism: Homo sapiens
Interactions: 113
UniProt ID: P07996

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001786 - phosphatidylserine binding
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464428

TSP3
Thrombospondin-3

3

17

High-throughput

0.861

High

464441

LRP1
Prolow-density lipoprotein receptor-related protein 1

3

9

Small-scale

0.845

High

464421

TSP2
Thrombospondin-2

2

16

High-throughput

0.811

High

464440

CO7A1
Collagen alpha-1(VII) chain

2

12

Small-scale

0.786

High

384086

CO1A1
Collagen alpha-1(I) chain

2

8

Small-scale

0.778

High

464470

SIRPD
Signal-regulatory protein delta

1

5

High-throughput

0.691

High

464478

OPT
Opticin

1

17

High-throughput

0.691

High

464481

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

13

High-throughput

0.691

High

388917

FINC
Fibronectin

3

7

Small-scale

0.660

High

384230

CO2A1
Collagen alpha-1(II) chain

1

8

Small-scale

0.647

High

384275

CO3A1

1

8

Small-scale

0.647

High

464409

CO6A1

1

6

Small-scale

0.647

High

464417

PGS1
Biglycan

1

20

Small-scale

0.647

High

464438

LRP2
Low-density lipoprotein receptor-related protein 2

1

6

Small-scale

0.647

High

464449

PCOC1
Procollagen C-endopeptidase enhancer 1

1

10

Small-scale

0.647

High

464432

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.628

High

464399

TSP1
Thrombospondin-1

1

16

Small-scale

0.621

High

464423

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

17

Small-scale

0.621

High

464422

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

18

Small-scale

0.618

High

366316

PLMN
Plasminogen

2

16

Small-scale

0.602

High

376675

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

2

7

Small-scale

0.595

High

423996

ITB3
Integrin beta-3

2

13

Small-scale

0.595

High

464437

TSG6
Tumor necrosis factor-inducible gene 6 protein

2

8

Small-scale

0.595

High

464472

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.574

High

464401

MMP2
72 kDa type IV collagenase

1

8

Small-scale

0.552

High

421329

A4
Amyloid-beta precursor protein

1

16

Small-scale

0.536

High

464415

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.536

High

464418

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

Small-scale

0.536

High

224461

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

342490

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.536

High

464404

LEG1
Galectin-1

1

18

High-throughput

0.536

High

464406

CFC1
Cryptic protein

1

4

High-throughput

0.536

High

464411

PRG2
Bone marrow proteoglycan

1

12

High-throughput

0.536

High

464427

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.536

High

464431

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.536

High

464453

LYPD4
Ly6/PLAUR domain-containing protein 4

1

3

High-throughput

0.536

High

464454

LYZL1
Lysozyme-like protein 1

1

4

High-throughput

0.536

High

464462

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.536

High

464469

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

464471

KLK15
Kallikrein-15

1

17

High-throughput

0.536

High

464479

DNJB9
DnaJ homolog subfamily B member 9

1

2

High-throughput

0.536

High

464450

ELAV1
ELAV-like protein 1

1

1

Small-scale

0.515

High

334145

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

464448

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

131676

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

Small-scale

0.501

High

366088

THRB
Prothrombin

1

15

Small-scale

0.501

High

376368

PDGFB
Platelet-derived growth factor subunit B

1

8

Small-scale

0.501

High

384296

CO4A1

1

8

Small-scale

0.501

High

387690

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

3

Small-scale

0.501

High

461041

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

464400

ELNE
Neutrophil elastase

1

20

Small-scale

0.501

High

464403

FGF2
Fibroblast growth factor 2

1

1

Small-scale

0.501

High

464407

TFPI1
Tissue factor pathway inhibitor

1

11

Small-scale

0.501

High

464408

COBA1

1

8

Small-scale

0.501

High

464416

CO5A1

1

8

Small-scale

0.501

High

464419

IBP5
Insulin-like growth factor-binding protein 5

1

8

Small-scale

0.501

High

464420

CALCR
Calcitonin receptor

1

1

Small-scale

0.501

High

464425

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

7

Small-scale

0.501

High

464447

SCRB2
Lysosome membrane protein 2

1

1

Small-scale

0.501

High

464444

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.494

High

158396

RFXK
DNA-binding protein RFXANK

1

14

High-throughput

0.489

High

464429

NEK4
Serine/threonine-protein kinase Nek4

1

9

High-throughput

0.489

High

464468

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.489

High

464477

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.489

High

464480

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.489

High

180470

PLS1
Phospholipid scramblase 1

1

7

Small-scale

0.481

High

464436

JAG1
Protein jagged-1

1

18

Small-scale

0.481

High

464445

LAMB3
Laminin subunit beta-3

1

20

Small-scale

0.481

High

192430

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.479

High

217729

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

403745

GCR
Glucocorticoid receptor

1

8

High-throughput

0.479

High

431660

ITB1
Integrin beta-1

1

9

Small-scale

0.479

High

447956

ITAV
Integrin alpha-V

1

2

Small-scale

0.479

High

464405

SPRC
SPARC

1

5

Small-scale

0.479

High

464410

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.479

High

464412

MMP9
Matrix metalloproteinase-9

1

8

Small-scale

0.479

High

464413

VEGFA
Vascular endothelial growth factor A, long form

1

8

Small-scale

0.479

High

464414

TIMP2
Metalloproteinase inhibitor 2

1

5

High-throughput

0.479

High

464426

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

464456

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.479

High

464467

ZDH15
Palmitoyltransferase ZDHHC15

1

2

Small-scale

0.479

High

464482

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.479

High

464402

PLEK
Pleckstrin

1

0

Small-scale

0.464

High

464424

MYH9
Myosin-9

1

0

Small-scale

0.458

High

464435

H31
Histone H3.1

1

0

High-throughput

0.458

High

464461

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

464451

ECM1
Extracellular matrix protein 1

1

1

Small-scale

0.457

High

464458

SULF2
Extracellular sulfatase Sulf-2

1

5

High-throughput

0.445

High

464464

HTRA1
Serine protease HTRA1

1

2

Small-scale

0.445

High

277256

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

464433

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

464434

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

464439

E2F1
Transcription factor E2F1

1

1

Small-scale

0.437

High

464455

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

464463

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

464476

ANLN
Anillin

1

3

High-throughput

0.437

High

464460

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

464446

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

9

High-throughput

0.407

High

134527

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.279

Low

298137

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

359783

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

464443

SCRN3
Secernin-3

1

0

High-throughput

0.279

Low

464457

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

464459

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

464465

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

464466

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

464473

AGO3
Protein argonaute-3

1

0

High-throughput

0.279

Low

464474

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

464430

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low

464452

PHF19
PHD finger protein 19

1

0

Small-scale

0.249

Low

464475

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

464442

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025