HitPredict

Interactor 1: PLOD3 (O60568)
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]
Gene: PLOD3

Interactor 2: COLA1 (Q96P44)
Collagen alpha-1(XXI) chain
Gene: COL21A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 738 Hs			1 957
+	Hs
		129937 PLOD2_HUMAN (19-738): 0: 1217: 58.75		COLA1_HUMAN (1-957): 3.12e-163: 504: 100.00
+	Hs
		972805 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COLA1_HUMAN (1-957): 3.12e-163: 504: 100.00
+	Hs
		237054 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO9A2_HUMAN (315-819): 3.68e-46: 179: 24.70
+	Hs
		237016 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A2_HUMAN (230-665): 2.45e-34: 145: 21.44
+	Hs
		237006 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A1_HUMAN (403-956): 8.69e-31: 133: 30.96
+	Hs
		237048 PLOD3_HUMAN (1-738): 0: 1310: 100.00		COGA1_HUMAN (422-816): 1e-15: 84.6: 34.72
+	Hs
		237114 PLOD3_HUMAN (1-738): 0: 1310: 100.00		COCA1_HUMAN (688-878): 2.83e-14: 80.1: 30.00
+	Hs
		237052 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A6_HUMAN (717-954): 3.69e-13: 76.2: 25.64
+	Hs
		237020 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO6A2_HUMAN (7-278): 2.26e-09: 63.4: 18.52
+	Hs
		441060 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A2_HUMAN (230-665): 2.45e-34: 145: 21.44
+	Hs
		358604 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO2A1_HUMAN (248-741): 2e-32: 138: 21.85
+	Hs
		358661 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A1_HUMAN (403-956): 8.69e-31: 133: 30.96
+	Hs
		129885 PLOD2_HUMAN (19-738): 0: 1217: 58.75		CO6A2_HUMAN (7-278): 2.26e-09: 63.4: 18.52
+	Hs
		972727 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COGA1_HUMAN (422-816): 1e-15: 84.6: 34.72
+	Hs
		972806 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COCA1_HUMAN (688-878): 2.83e-14: 80.1: 30.00
+	Hs
		972738 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A6_HUMAN (717-954): 3.69e-13: 76.2: 25.64
+	Hs
		972726 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COEA1_HUMAN (303-546): 1.88e-10: 67.4: 15.96
+	Hs
		972810 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COPA1_HUMAN (464-638): 8.46e-10: 64.7: 42.19
+	Hs
		517998 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO6A2_HUMAN (7-278): 2.26e-09: 63.4: 18.52
+	Dm
		435988 PLOD_DROME (37-738): 0: 1033: 46.03		CO4A1_DROME (795-953): 1.72e-10: 67.4: 25.00