Protein: KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)

Gene: KCC2G, CAMK2G
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q13555

Gene Ontology (top 5):
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110332

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

9

16

Small-scale

0.973

High

1110426

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

7

16

High-throughput

0.964

High

1110235

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

4

17

High-throughput

0.902

High

1110413

ANLN
Anillin

3

2

High-throughput

0.847

High

1110353

RHG29
Rho GTPase-activating protein 29

3

5

High-throughput

0.839

High

1105910

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

5

High-throughput

0.811

High

1110405

RBM42
RNA-binding protein 42

2

3

High-throughput

0.811

High

933927

RAD
GTP-binding protein RAD

2

2

Small-scale

0.799

High

1110331

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

2

15

Small-scale

0.799

High

1110368

CK2N1
Calcium/calmodulin-dependent protein kinase II inhibitor 1

2

6

High-throughput

0.789

High

1110346

CDC37
Hsp90 co-chaperone Cdc37

2

4

High-throughput

0.783

High

1110359

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

4

High-throughput

0.783

High

838934

RHG25
Rho GTPase-activating protein 25

3

5

High-throughput

0.731

High

213927

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

6

Small-scale

0.724

High

463088

YES
Tyrosine-protein kinase Yes

1

12

High-throughput

0.691

High

586290

ZEP1
Zinc finger protein 40

1

3

High-throughput

0.691

High

692691

CALL3
Calmodulin-like protein 3

1

20

High-throughput

0.691

High

717801

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.691

High

727501

ZEP2
Transcription factor HIVEP2

1

3

High-throughput

0.691

High

1110341

MELK
Maternal embryonic leucine zipper kinase

1

11

High-throughput

0.691

High

1110342

SLMAP
Sarcolemmal membrane-associated protein

1

2

High-throughput

0.691

High

1110361

PKN3
Serine/threonine-protein kinase N3

1

9

High-throughput

0.691

High

1110391

CALL4
Calmodulin-like protein 4

1

20

High-throughput

0.691

High

1110399

CK2N2
Calcium/calmodulin-dependent protein kinase II inhibitor 2

1

6

High-throughput

0.691

High

1110412

PAK6
Serine/threonine-protein kinase PAK 6

1

10

High-throughput

0.691

High

1110424

CILK1
Serine/threonine-protein kinase ICK

1

12

High-throughput

0.691

High

946656

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

3

1

High-throughput

0.667

High

468347

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.665

High

404037

GCR
Glucocorticoid receptor

3

10

High-throughput

0.650

High

1110339

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

2

11

High-throughput

0.628

High

74482

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.618

High

461451

HS90A
Heat shock protein HSP 90-alpha

1

15

High-throughput

0.618

High

958429

ACTZ
Alpha-centractin

1

7

High-throughput

0.618

High

1107686

SQSTM
Sequestosome-1

1

5

Small-scale

0.618

High

1110364

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1110387

KPBB
Phosphorylase b kinase regulatory subunit beta

1

2

High-throughput

0.618

High

1110407

KPCD2
Serine/threonine-protein kinase D2

1

18

High-throughput

0.618

High

1110410

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.618

High

1110411

MYO10
Unconventional myosin-X

1

2

Small-scale

0.618

High

1110427

NINL
Ninein-like protein

1

4

High-throughput

0.618

High

1110431

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.618

High

900312

FXR2
RNA-binding protein FXR2

2

18

High-throughput

0.614

High

909433

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

2

High-throughput

0.609

High

164570

TNPO2
Transportin-2

2

3

High-throughput

0.606

High

633676

PSB1
Proteasome subunit beta type-1

2

1

High-throughput

0.606

High

965545

NTF2
Nuclear transport factor 2

2

1

High-throughput

0.606

High

976893

ERR3
Estrogen-related receptor gamma

2

10

High-throughput

0.606

High

1110351

KRA61
Keratin-associated protein 6-1

2

1

High-throughput

0.606

High

1110360

DUS1L
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

2

2

High-throughput

0.606

High

1110367

KR193
Keratin-associated protein 19-3

2

2

High-throughput

0.606

High

1110375

TTC5
Tetratricopeptide repeat protein 5

2

3

High-throughput

0.606

High

1110401

STRBP
Spermatid perinuclear RNA-binding protein

2

2

High-throughput

0.606

High

1110418

NXF1
Nuclear RNA export factor 1

2

1

High-throughput

0.606

High

1110430

TNPO3
Transportin-3

2

5

High-throughput

0.606

High

1110333

CUL3
Cullin-3

2

8

High-throughput

0.601

High

791367

SYUA
Alpha-synuclein

2

2

Small-scale

0.595

High

1098518

NMDE2
Glutamate receptor ionotropic, NMDA 2B

2

16

Small-scale

0.595

High

951660

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.578

High

1110371

T200A
Transmembrane protein 200A

2

0

High-throughput

0.576

High

516336

CALM1
Calmodulin-1

1

20

High-throughput

0.575

High

516410

CALM2
Calmodulin-2

1

20

High-throughput

0.575

High

516512

CALM3
Calmodulin-3

1

20

High-throughput

0.575

High

581029

RAC2
Ras-related C3 botulinum toxin substrate 2

1

15

High-throughput

0.575

High

1110355

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.575

High

1110429

RM11
Large ribosomal subunit protein uL11m

2

3

High-throughput

0.553

High

899883

FXR1
RNA-binding protein FXR1

1

18

High-throughput

0.541

High

128217

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

High-throughput

0.536

High

185670

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.536

High

228586

STRN
Striatin

1

8

High-throughput

0.536

High

247113

TBCD4
TBC1 domain family member 4

1

1

High-throughput

0.536

High

278078

FLNB
Filamin-B

1

8

High-throughput

0.536

High

322935

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

1

High-throughput

0.536

High

354855

DNAL4
Dynein axonemal light chain 4

1

3

High-throughput

0.536

High

504690

F163B
Protein FAM163B

1

2

High-throughput

0.536

High

655814

TBG1
Tubulin gamma-1 chain

1

8

High-throughput

0.536

High

698214

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

6

High-throughput

0.536

High

702103

ITPI2
Protein ITPRID2

1

3

High-throughput

0.536

High

729810

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

755909

MCM5
DNA replication licensing factor MCM5

1

4

High-throughput

0.536

High

862836

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

12

High-throughput

0.536

High

866671

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.536

High

966282

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

971493

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.536

High

990191

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

991517

DYL1
Dynein light chain 1, cytoplasmic

1

3

High-throughput

0.536

High

1005318

IGBP1
Immunoglobulin-binding protein 1

1

1

High-throughput

0.536

High

1008428

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

5

High-throughput

0.536

High

1049266

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1089196

TRI26
Tripartite motif-containing protein 26

1

5

High-throughput

0.536

High

1092875

STRN3
Striatin-3

1

9

High-throughput

0.536

High

1110336

SRC8
Src substrate cortactin

1

6

High-throughput

0.536

High

1110338

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

11

High-throughput

0.536

High

1110340

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

11

High-throughput

0.536

High

1110343

PON2
Serum paraoxonase/arylesterase 2

1

1

High-throughput

0.536

High

1110347

DREB
Drebrin

1

6

High-throughput

0.536

High

1110363

SHSA6
Protein shisa-6

1

2

High-throughput

0.536

High

1110372

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.536

High

1110373

DZIP1
Cilium assembly protein DZIP1

1

4

High-throughput

0.536

High

1110378

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

1110383

THOC2
THO complex subunit 2

1

2

High-throughput

0.536

High

1110388

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

1110390

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.536

High

1110400

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.536

High

1110408

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1110414

STRN4
Striatin-4

1

7

High-throughput

0.536

High

1110421

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

4

High-throughput

0.536

High

1110425

BAIP2
BAR/IMD domain-containing adapter protein 2

1

3

High-throughput

0.536

High

1110428

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.536

High

933939

NR1H2
Oxysterols receptor LXR-beta

1

6

Small-scale

0.516

High

1110352

KRA63
Keratin-associated protein 6-3

1

2

High-throughput

0.515

High

1110366

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.515

High

255007

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.514

High

261494

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

1110357

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.513

High

1110358

STRP1
Striatin-interacting protein 1

1

0

High-throughput

0.513

High

1110377

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

0

High-throughput

0.513

High

1110379

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

1110382

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

1110386

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

1110416

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.513

High

1110423

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

1051659

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

16

Small-scale

0.501

High

1106523

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.501

High

1110345

SMAD2
Mothers against decapentaplegic homolog 2

1

3

Small-scale

0.501

High

1110396

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

2

Small-scale

0.501

High

848616

MAGA9
Melanoma-associated antigen 9

1

6

High-throughput

0.489

High

1110349

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

1110354

KLH26
Kelch-like protein 26

1

4

High-throughput

0.489

High

1110376

PUSL1
tRNA pseudouridine synthase-like 1

1

2

High-throughput

0.489

High

1110394

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1110402

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1110403

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.489

High

1110417

MAP10
Microtubule-associated protein 10

1

3

High-throughput

0.489

High

1110422

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.489

High

993553

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

599586

STMN1
Stathmin

1

0

Small-scale

0.480

High

135608

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.479

High

227870

MYO1B
Unconventional myosin-Ib

1

3

High-throughput

0.479

High

258597

SH21A
SH2 domain-containing protein 1A

1

14

High-throughput

0.479

High

301039

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.479

High

323362

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.479

High

345772

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

371961

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

459580

PROF1
Profilin-1

1

1

Small-scale

0.479

High

551029

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

588634

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

637895

NF1
Neurofibromin

1

12

High-throughput

0.479

High

695393

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

768126

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

867102

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

977484

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

8

High-throughput

0.479

High

994211

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

8

High-throughput

0.479

High

1004533

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1035599

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1109697

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1110334

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

1110344

MARE1
Microtubule-associated protein RP/EB family member 1

1

3

Small-scale

0.479

High

1110350

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1110356

DACT2
Dapper homolog 2

1

3

High-throughput

0.479

High

1110365

CBAR2
CBY1-interacting BAR domain-containing protein 2

1

2

High-throughput

0.479

High

1110374

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.479

High

1110384

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1110385

TF2H4
General transcription factor IIH subunit 4

1

2

High-throughput

0.479

High

1110389

PF21A
PHD finger protein 21A

1

1

High-throughput

0.479

High

1110393

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1110409

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1110419

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

4

Small-scale

0.479

High

1110420

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

186257

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.458

High

246587

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

353868

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

1110337

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1110381

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

404781

PRIO
Major prion protein

1

3

High-throughput

0.445

High

488218

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

1

Small-scale

0.445

High

756184

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.445

High

1103150

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

1110335

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

1110348

TPD53
Tumor protein D53

1

2

High-throughput

0.445

High

1110369

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

8

High-throughput

0.445

High

1110392

P121A
Nuclear envelope pore membrane protein POM 121

1

7

High-throughput

0.445

High

1110397

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

12

High-throughput

0.445

High

1110398

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1110406

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

2

Small-scale

0.445

High

105882

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

717078

ECHM
Enoyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.437

High

1110370

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

1110415

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

2

High-throughput

0.437

High

409374

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

1110362

PKHG7
Pleckstrin homology domain-containing family G member 7

1

10

High-throughput

0.407

High

1110380

GG6L2
Golgin subfamily A member 6-like protein 2

1

3

High-throughput

0.407

High

886833

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1110395

ZN488
Zinc finger protein 488

1

0

High-throughput

0.279

Low

1110404

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025