Protein: PAK3
Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)

Gene: PAK3
Organism: Homo sapiens
Interactions: 39
UniProt ID: O75914

Gene Ontology (top 5):
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

297095

CDC42
Cell division control protein 42 homolog

4

20

Small-scale

0.900

High

297098

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.843

High

297102

ARHG7
Rho guanine nucleotide exchange factor 7

2

16

Small-scale

0.793

High

297118

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

High-throughput

0.783

High

297100

PAK1
Serine/threonine-protein kinase PAK 1

1

17

High-throughput

0.691

High

297088

PAK3
Serine/threonine-protein kinase PAK 3

1

17

Small-scale

0.647

High

297093

PLK1
Serine/threonine-protein kinase PLK1

1

16

Small-scale

0.618

High

297096

ABCE1
ATP-binding cassette sub-family E member 1

1

3

High-throughput

0.618

High

297101

PAK2
Serine/threonine-protein kinase PAK 2

1

17

High-throughput

0.618

High

297105

MK14
Mitogen-activated protein kinase 14

1

15

Small-scale

0.618

High

297108

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

297114

PALLD
Palladin

1

5

High-throughput

0.618

High

297119

GIT1
ARF GTPase-activating protein GIT1

1

13

Small-scale

0.618

High

167484

TX1B3
Tax1-binding protein 3

2

13

High-throughput

0.601

High

297099

STK4
Serine/threonine-protein kinase 4

1

17

High-throughput

0.575

High

297112

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

2

High-throughput

0.574

High

297090

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.571

High

297091

ITB8
Integrin beta-8

1

8

High-throughput

0.536

High

297106

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

297115

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

6

High-throughput

0.536

High

297116

RM38
Large ribosomal subunit protein mL38

1

3

High-throughput

0.536

High

297110

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.513

High

297120

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.513

High

297092

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

256720

H2B1K
Histone H2B type 1-K

1

19

High-throughput

0.479

High

297089

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.479

High

297097

H2B1C
Histone H2B type 1-C/E/F/G/I

1

19

High-throughput

0.479

High

297104

ITSN1
Intersectin-1

1

16

Small-scale

0.479

High

221991

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.445

High

253927

LPXN
Leupaxin

1

8

High-throughput

0.445

High

297094

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

297103

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.445

High

297107

TM154
Transmembrane protein 154

1

1

High-throughput

0.407

High

297109

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.279

Low

297111

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.279

Low

297117

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.279

Low

297121

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

297113

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025