HitPredict

Interactor 1: IMA7 (O60684)
Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Gene: KPNA6

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~Ras, Arm_3~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 192
+	Hs
		134868 IMA3_HUMAN (4-536): 9.52e-152: 446: 47.10		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		853562 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		545276 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		853234 IMA1_HUMAN (1-536): 5.59e-142: 421: 44.92		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		853554 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		853556 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436216 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		853220 IMA1_HUMAN (1-536): 5.59e-142: 421: 44.92		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31