Protein: AATC
Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)

Gene: AATC, GOT1
Organism: Homo sapiens
Interactions: 212
UniProt ID: P17174

Gene Ontology (top 5):
GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609 - phosphatidylserine decarboxylase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602817

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

5

High-throughput

0.811

High

442226

GELS
Gelsolin

2

1

High-throughput

0.611

High

240682

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

362721

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

602772

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

602755

CCR2
C-C chemokine receptor type 2

1

1

High-throughput

0.541

High

602834

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.541

High

85950

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

9

High-throughput

0.536

High

133167

QSOX1
Sulfhydryl oxidase 1

1

1

High-throughput

0.536

High

139049

LAD1
Ladinin-1

1

2

High-throughput

0.536

High

220076

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.536

High

227055

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

238654

AK1BA
Aldo-keto reductase family 1 member B10

1

6

High-throughput

0.536

High

248669

PEPL
Periplakin

1

4

High-throughput

0.536

High

277548

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.536

High

289239

SPB7
Serpin B7

1

8

High-throughput

0.536

High

348849

CLIC3
Chloride intracellular channel protein 3

1

2

High-throughput

0.536

High

366093

THRB
Prothrombin

1

1

High-throughput

0.536

High

366327

PLMN
Plasminogen

1

1

High-throughput

0.536

High

369435

AACT
Alpha-1-antichymotrypsin

1

7

High-throughput

0.536

High

369826

CO3
Complement C3

1

3

High-throughput

0.536

High

387224

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

387697

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

High-throughput

0.536

High

387783

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.536

High

387945

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.536

High

390858

TRFE
Serotransferrin

1

1

High-throughput

0.536

High

390990

TRFL
Lactotransferrin

1

1

High-throughput

0.536

High

402842

ANXA1
Annexin A1

1

4

High-throughput

0.536

High

424130

S10A8
Protein S100-A8

1

4

High-throughput

0.536

High

424481

PAI2
Plasminogen activator inhibitor 2

1

8

High-throughput

0.536

High

444894

S10A9
Protein S100-A9

1

6

High-throughput

0.536

High

479197

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

501799

CO4A
Complement C4-A

1

3

High-throughput

0.536

High

505859

PA24B
Cytosolic phospholipase A2 beta

1

1

High-throughput

0.536

High

555858

CADH1
Cadherin-1

1

1

High-throughput

0.536

High

568117

PLSL
Plastin-2

1

3

High-throughput

0.536

High

568943

ANXA8
Annexin A8

1

4

High-throughput

0.536

High

582655

EZRI
Ezrin

1

2

High-throughput

0.536

High

587551

DESP
Desmoplakin

1

5

High-throughput

0.536

High

602727

LEG3
Galectin-3

1

1

High-throughput

0.536

High

602728

IL1RA
Interleukin-1 receptor antagonist protein

1

3

High-throughput

0.536

High

602730

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.536

High

602731

ICAL
Calpastatin

1

1

High-throughput

0.536

High

602732

FILA
Filaggrin

1

3

High-throughput

0.536

High

602734

CD9
CD9 antigen

1

1

High-throughput

0.536

High

602735

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

602736

S100P
Protein S100-P

1

6

High-throughput

0.536

High

602739

RABP2
Cellular retinoic acid-binding protein 2

1

1

High-throughput

0.536

High

602740

SPB3
Serpin B3

1

8

High-throughput

0.536

High

602744

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

602745

ILEU
Leukocyte elastase inhibitor

1

8

High-throughput

0.536

High

602746

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.536

High

602747

S10A7
Protein S100-A7

1

6

High-throughput

0.536

High

602749

1433S
14-3-3 protein sigma

1

2

High-throughput

0.536

High

602750

DSG3
Desmoglein-3

1

3

High-throughput

0.536

High

602752

SPB5
Serpin B5

1

8

High-throughput

0.536

High

602753

CAPG
Macrophage-capping protein

1

1

High-throughput

0.536

High

602759

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.536

High

602760

LEG7
Galectin-7

1

1

High-throughput

0.536

High

602762

SPB4
Serpin B4

1

8

High-throughput

0.536

High

602764

SPB8
Serpin B8

1

8

High-throughput

0.536

High

602766

AK1C2
Aldo-keto reductase family 1 member C2

1

6

High-throughput

0.536

High

602768

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.536

High

602769

EPIPL
Epiplakin

1

5

High-throughput

0.536

High

602770

RAB5B
Ras-related protein Rab-5B

1

1

High-throughput

0.536

High

602773

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.536

High

602775

DSG1
Desmoglein-1

1

3

High-throughput

0.536

High

602776

DSC2
Desmocollin-2

1

3

High-throughput

0.536

High

602780

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.536

High

602781

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.536

High

602784

PKP1
Plakophilin-1

1

2

High-throughput

0.536

High

602788

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.536

High

602791

PLEC
Plectin

1

3

High-throughput

0.536

High

602809

S1A7A
Protein S100-A7A

1

6

High-throughput

0.536

High

602810

FCSD1
F-BAR and double SH3 domains protein 1

1

1

High-throughput

0.536

High

602814

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.536

High

602815

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

2

High-throughput

0.536

High

602824

EVPL
Envoplakin

1

5

High-throughput

0.536

High

602827

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.536

High

602842

IL36G
Interleukin-36 gamma

1

3

High-throughput

0.536

High

602843

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.536

High

602844

I36RA
Interleukin-36 receptor antagonist protein

1

3

High-throughput

0.536

High

602845

ZO2
Tight junction protein 2

1

1

High-throughput

0.536

High

602846

IL36A
Interleukin-36 alpha

1

3

High-throughput

0.536

High

602849

DBNL
Drebrin-like protein

1

1

High-throughput

0.536

High

602854

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

4

High-throughput

0.536

High

602857

PKP3
Plakophilin-3

1

2

High-throughput

0.536

High

578370

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.525

High

215249

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.515

High

602811

PA24D
Cytosolic phospholipase A2 delta

1

3

High-throughput

0.515

High

602839

S10AE
Protein S100-A14

1

6

High-throughput

0.515

High

126224

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

183326

ZN185
Zinc finger protein 185

1

0

High-throughput

0.513

High

226396

SNG2
Synaptogyrin-2

1

0

High-throughput

0.513

High

253048

PLIN3
Perilipin-3

1

0

High-throughput

0.513

High

276563

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.513

High

348897

EMAL2
Echinoderm microtubule-associated protein-like 2

1

0

High-throughput

0.513

High

350276

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.513

High

359919

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.513

High

389952

ALBU
Albumin

1

0

High-throughput

0.513

High

427795

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.513

High

457833

INVO
Involucrin

1

0

High-throughput

0.513

High

472270

CFAH
Complement factor H

1

0

High-throughput

0.513

High

483880

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

502229

H2A1
Histone H2A type 1

1

0

High-throughput

0.513

High

551602

NFH
Neurofilament heavy polypeptide

1

0

High-throughput

0.513

High

567738

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.513

High

572977

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

577603

PLAK
Junction plakoglobin

1

0

High-throughput

0.513

High

582542

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

591213

CD44
CD44 antigen

1

0

High-throughput

0.513

High

595302

H15
Histone H1.5

1

0

High-throughput

0.513

High

602729

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

602733

ENDOU
Uridylate-specific endoribonuclease

1

0

High-throughput

0.513

High

602737

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

602741

BLVRB
Flavin reductase

1

0

High-throughput

0.513

High

602742

KCY
UMP-CMP kinase

1

0

High-throughput

0.513

High

602748

CASPE
Caspase-14

1

0

High-throughput

0.513

High

602756

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

602758

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

602761

XDH
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

1

0

High-throughput

0.513

High

602767

BIEA
Biliverdin reductase A

1

0

High-throughput

0.513

High

602771

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

602774

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

602783

FCL
GDP-L-fucose synthase

1

0

High-throughput

0.513

High

602789

MVP
Major vault protein

1

0

High-throughput

0.513

High

602790

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

602793

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.513

High

602798

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.513

High

602800

STEA4
Metalloreductase STEAP4

1

0

High-throughput

0.513

High

602804

SBSN
Suprabasin

1

0

High-throughput

0.513

High

602805

FA83H
Protein FAM83H

1

0

High-throughput

0.513

High

602807

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

602812

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

602818

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.513

High

602822

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

602826

PGM2
Phosphopentomutase

1

0

High-throughput

0.513

High

602828

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

602829

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

602830

NIBA2
Protein Niban 2

1

0

High-throughput

0.513

High

602831

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

602832

TPPP3
Tubulin polymerization-promoting protein family member 3

1

0

High-throughput

0.513

High

602836

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

602837

GAN
Gigaxonin

1

0

High-throughput

0.513

High

602838

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

0

High-throughput

0.513

High

602840

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.513

High

602848

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

602851

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.513

High

602852

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

High-throughput

0.513

High

602855

GUAD
Guanine deaminase

1

0

High-throughput

0.513

High

602856

STA10
START domain-containing protein 10

1

0

High-throughput

0.513

High

547086

PYC
Pyruvate carboxylase, mitochondrial

1

1

Small-scale

0.501

High

602743

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.494

High

602777

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.493

High

602803

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.493

High

210702

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

602763

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

602825

OSTF1
Osteoclast-stimulating factor 1

1

3

High-throughput

0.489

High

602858

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

1

High-throughput

0.489

High

602859

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

1

High-throughput

0.489

High

123325

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

379862

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

587863

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

602738

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

602754

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.479

High

602765

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

602794

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

602806

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

602813

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

602821

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

602850

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

602853

UBQL1
Ubiquilin-1

1

2

High-throughput

0.479

High

385431

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

602726

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

602782

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

602816

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

602823

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

69474

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.445

High

379070

IGKC
Immunoglobulin kappa constant

1

9

High-throughput

0.445

High

379210

IGHG1
Immunoglobulin heavy constant gamma 1

1

7

High-throughput

0.445

High

379334

IGHG2
Immunoglobulin heavy constant gamma 2

1

7

High-throughput

0.445

High

379420

IGHG3
Immunoglobulin heavy constant gamma 3

1

6

High-throughput

0.445

High

379452

IGHG4
Immunoglobulin heavy constant gamma 4

1

7

High-throughput

0.445

High

379488

IGHM
Immunoglobulin heavy constant mu

1

6

High-throughput

0.445

High

529022

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

602757

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.445

High

602785

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

602796

AXA81
Annexin A8-like protein 1

1

4

High-throughput

0.445

High

75653

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

105278

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

602751

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

602787

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

602795

H37
Histone H3-7

1

0

High-throughput

0.426

High

602808

TARSH
Target of Nesh-SH3

1

0

High-throughput

0.282

High

51307

NTM2F
NUT family member 2F

1

0

High-throughput

0.279

Low

261597

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

296396

RBBP9
Serine hydrolase RBBP9

1

0

High-throughput

0.279

Low

326655

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

602778

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.279

Low

602779

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.279

Low

602786

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

602792

CDSN
Corneodesmosin

1

0

High-throughput

0.279

Low

602797

TT39B
Tetratricopeptide repeat protein 39B

1

0

High-throughput

0.279

Low

602799

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.279

Low

602801

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

602819

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

602820

TMM40
Transmembrane protein 40

1

0

High-throughput

0.279

Low

602835

ELOV4
Very long chain fatty acid elongase 4

1

0

High-throughput

0.279

Low

602841

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.279

Low

602847

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

602802

DMKN
Dermokine

1

0

High-throughput

0.269

Low

602833

TACAN
Transmembrane protein 120A

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025