HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Ion_trans
Common GO terms	GO:0030424 - axon
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 7570
+	Hs
		239945 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		164538 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTN2_HUMAN (5708-7163): 4.91e-17: 92.5: 14.91
+	Hs
		239982 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		240002 HCN1_HUMAN (1-890): 0: 684: 100.00		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		239884 HCN1_HUMAN (1-890): 0: 684: 100.00		EPIPL_HUMAN (1651-1891): 1.02e-10: 71.7: 20.73
+	Hs
		239659 HCN1_HUMAN (1-890): 0: 684: 100.00		K0754_HUMAN (1218-1826): 6.86e-10: 69: 10.48
+	Hs
		240102 HCN1_HUMAN (1-890): 0: 684: 100.00		SYNE1_HUMAN (147-1832): 6.65e-10: 69: 8.83
+	Mm
		292126 HCN1_MOUSE (1-890): 0: 651: 90.35		SPTB2_MOUSE (6042-7200): 1.95e-19: 100: 13.42
+	Mm
		292129 HCN1_MOUSE (1-890): 0: 651: 90.35		Q68FG2_MOUSE (257-1285): 4.95e-09: 65.9: 9.28