Protein: BBX
HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)

Gene: BBX
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q8WY36

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904976

MECP2
Methyl-CpG-binding protein 2

3

11

High-throughput

0.667

High

1109940

HDAC1
Histone deacetylase 1

3

16

High-throughput

0.662

High

302077

SEGN
Secretagogin

3

0

High-throughput

0.638

High

1361385

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

10

High-throughput

0.628

High

1361386

ZN512
Zinc finger protein 512

2

7

High-throughput

0.628

High

1361399

H2AW
Core histone macro-H2A.2

2

4

High-throughput

0.628

High

1361403

ARI1
E3 ubiquitin-protein ligase ARIH1

2

1

High-throughput

0.628

High

668676

APC
Adenomatous polyposis coli protein

1

19

High-throughput

0.618

High

1361390

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

8

High-throughput

0.609

High

1219031

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

980963

H2B1C
Histone H2B type 1-C/E/F/G/I

2

2

High-throughput

0.584

High

998606

H31
Histone H3.1

2

12

High-throughput

0.584

High

687271

HMGB2
High mobility group protein B2

1

20

High-throughput

0.575

High

1037571

RL18A
Large ribosomal subunit protein eL20

2

1

High-throughput

0.574

High

1361384

TRI44
Tripartite motif-containing protein 44

2

5

High-throughput

0.574

High

396608

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

1066418

RBBP4
Histone-binding protein RBBP4

2

15

High-throughput

0.571

High

422737

A4
Amyloid-beta precursor protein

2

5

High-throughput

0.550

High

290655

SURF6
Surfeit locus protein 6

2

1

High-throughput

0.549

High

74562

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

13

High-throughput

0.536

High

191732

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.536

High

274360

SIN3B
Paired amphipathic helix protein Sin3b

1

7

High-throughput

0.536

High

428883

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.536

High

659544

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.536

High

711783

ARI4A
AT-rich interactive domain-containing protein 4A

1

20

High-throughput

0.536

High

785327

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

824263

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.536

High

854193

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

855152

NOP2
28S rRNA

1

2

High-throughput

0.536

High

960818

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

973245

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.536

High

1008818

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.536

High

1089767

ILF3
Interleukin enhancer-binding factor 3

1

12

High-throughput

0.536

High

1117618

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.536

High

1123060

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1281433

ZN467
Zinc finger protein 467

1

5

High-throughput

0.536

High

1361383

ZN653
Zinc finger protein 653

1

4

High-throughput

0.536

High

1361393

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.536

High

1361398

FOXJ2
Forkhead box protein J2

1

20

High-throughput

0.536

High

96732

E9PAV9
G patch domain-containing protein 4

2

2

High-throughput

0.533

High

768762

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.533

High

1361401

RL26L
Ribosomal protein uL24-like

2

1

High-throughput

0.521

High

843817

HD
Huntingtin

1

2

High-throughput

0.515

High

1361391

TRI54
Tripartite motif-containing protein 54

1

7

High-throughput

0.494

High

657279

KALM
Anosmin-1

1

1

High-throughput

0.489

High

718440

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.489

High

859005

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.489

High

859927

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.489

High

902868

BLK
Tyrosine-protein kinase Blk

1

3

High-throughput

0.489

High

970002

RS16
Small ribosomal subunit protein uS9

1

4

High-throughput

0.489

High

1099460

SRSF6
Serine/arginine-rich splicing factor 6

1

15

High-throughput

0.489

High

1361388

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

143143

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

372701

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

386034

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

14

High-throughput

0.479

High

406438

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

461764

HS90A
Heat shock protein HSP 90-alpha

1

6

High-throughput

0.479

High

468651

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.479

High

472930

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

474156

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487582

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

504941

H2AB2
Histone H2A-Bbd type 2/3

1

1

High-throughput

0.479

High

521837

H14
Histone H1.4

1

2

High-throughput

0.479

High

558291

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

589277

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

664778

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.479

High

686846

S10A4
Protein S100-A4

1

8

High-throughput

0.479

High

696063

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

883635

CENPA
Histone H3-like centromeric protein A

1

12

High-throughput

0.479

High

951783

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

979099

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

980055

H4
Histone H4

1

3

High-throughput

0.479

High

986597

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

7

High-throughput

0.479

High

1017065

H33
Histone H3.3

1

12

High-throughput

0.479

High

1045578

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1087896

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1097451

CBX3
Chromobox protein homolog 3

1

12

High-throughput

0.479

High

1118664

KLF9
Krueppel-like factor 9

1

19

High-throughput

0.479

High

1133559

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1141239

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1276554

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1313298

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1361382

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1361389

KLF16
Krueppel-like factor 16

1

19

High-throughput

0.479

High

1361397

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1361402

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

194286

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

697197

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

770242

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

800011

COIL
Coilin

1

0

High-throughput

0.458

High

1185209

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.458

High

1361387

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

4

High-throughput

0.457

High

601782

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.445

High

1037295

H11
Histone H1.1

1

2

High-throughput

0.445

High

1361395

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1361396

SHCAF
SIN3-HDAC complex-associated factor

1

2

High-throughput

0.445

High

191022

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.437

High

451421

NFM
Neurofilament medium polypeptide

1

6

High-throughput

0.437

High

474863

VIME
Vimentin

1

6

High-throughput

0.437

High

900955

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.437

High

955425

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.437

High

1030673

ANK2
Ankyrin-2

1

2

High-throughput

0.437

High

1059604

SPAG1
Sperm-associated antigen 1

1

7

High-throughput

0.437

High

1071177

ARL16
ADP-ribosylation factor-like protein 16

1

6

High-throughput

0.437

High

1135262

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

High-throughput

0.437

High

1289954

LUZP1
Leucine zipper protein 1

1

10

High-throughput

0.437

High

1338869

NUP43
Nucleoporin Nup43

1

18

High-throughput

0.437

High

1361400

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

69962

A8KAG1
G patch domain-containing protein 4

1

2

High-throughput

0.407

High

985787

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.407

High

1212354

GPTC4
G patch domain-containing protein 4

1

2

High-throughput

0.407

High

294738

PR15A
Protein phosphatase 1 regulatory subunit 15A

2

0

High-throughput

0.328

High

948567

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

1009268

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1127447

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1208316

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1219246

CHIC1
Cysteine-rich hydrophobic domain-containing protein 1

1

0

High-throughput

0.279

Low

1348929

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

301596

WFS1
Wolframin

1

0

High-throughput

0.268

Low

984877

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

1361392

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

208325

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.232

Low

1139978

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.232

Low

1361394

GREM2
Gremlin-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025