HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: RIMS2 (Q9UQ26)
Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)
Gene: RIMS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042391 - regulation of membrane potential
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1411
+	Hs
		240013 HCN1_HUMAN (1-890): 0: 684: 100.00		CAC1E_HUMAN (1-515): 3.75e-78: 288: 12.31
+	Hs
		207681 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT7_HUMAN (1254-1379): 7.02e-22: 102: 19.58
+	Mm
		292117 HCN1_MOUSE (1-890): 0: 651: 90.35		RP3A_MOUSE (799-1032): 1.84e-30: 131: 17.53
+	Hs
		239777 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT1_HUMAN (807-931): 2.74e-18: 91.1: 23.20
+	Hs
		240099 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT2_HUMAN (796-954): 2.89e-18: 91.1: 23.27
+	Hs
		240147 HCN1_HUMAN (1-890): 0: 684: 100.00		NED4L_HUMAN (1258-1371): 3.65e-15: 83.2: 25.21
+	Hs
		239757 HCN1_HUMAN (1-890): 0: 684: 100.00		KPCA_HUMAN (1259-1378): 1.74e-13: 77.3: 28.69
+	Hs
		240315 HCN1_HUMAN (1-890): 0: 684: 100.00		PCLO_HUMAN (6-557): 5.22e-10: 66.7: 13.88
+	Hs
		135784 CNGA3_HUMAN (5-668): 1.46e-146: 451: 21.46		P3C2B_HUMAN (738-938): 3.58e-41: 168: 22.22
+	Hs
		1017025 KCNH2_HUMAN (3-883): 1.33e-165: 514: 18.18		NED4L_HUMAN (1258-1371): 3.65e-15: 83.2: 25.21
+	Hs
		1081484 CNGA3_HUMAN (5-668): 1.46e-146: 451: 21.46		ESYT1_HUMAN (1097-1382): 1.76e-13: 77.7: 16.17