HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 152
+	Hs
		240755 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		NDKB_HUMAN (1-152): 2.6e-92: 265: 88.16
+	Hs
		240281 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		NDK6_HUMAN (4-135): 1.06e-53: 169: 30.15
+	Hs
		243409 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		NDK7_HUMAN (7-135): 5.51e-40: 139: 28.57
+	Hs
		507078 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		NDKB_HUMAN (1-152): 2.6e-92: 265: 88.16
+	Hs
		507182 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		NDK3_HUMAN (5-152): 1.34e-83: 244: 67.57
+	At
		235542 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		NDK3_ARATH (2-151): 3.58e-83: 245: 62.00
+	At
		811726 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		NDK1_ARATH (4-152): 4.05e-81: 237: 62.42
+	At
		265657 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		NDK2_ARATH (1-152): 3.79e-79: 235: 53.95