HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 463
+	Hs
		243452 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16
+	Hs
		965867 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		HNRPK_HUMAN (1-463): 3.38e-139: 409: 100.00
+	Hs
		243150 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IF2B1_HUMAN (1-461): 7.01e-66: 223: 14.71
+	Hs
		335054 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		HNRPK_HUMAN (1-463): 3.38e-139: 409: 100.00
+	Hs
		1418858 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16
+	Hs
		241750 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PCBP2_HUMAN (127-222): 1.6e-12: 70.8: 29.17
+	Hs
		242587 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FUBP3_HUMAN (336-457): 3.82e-12: 70.4: 24.59
+	Hs
		241749 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PCBP1_HUMAN (7-111): 7.46e-12: 68.5: 14.95
+	Hs
		242491 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FUBP2_HUMAN (238-460): 3.96e-10: 64.2: 17.09
+	Hs
		242524 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FUBP1_HUMAN (214-460): 4.14e-10: 63.8: 16.73
+	Hs
		134982 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IF2B3_HUMAN (193-461): 4.23e-09: 60.7: 13.99
+	Hs
		1418819 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		IF2B1_HUMAN (1-461): 7.01e-66: 223: 14.71
+	Hs
		1146895 ARI1_HUMAN (163-464): 4.18e-73: 242: 19.67		PCBP1_HUMAN (7-111): 7.46e-12: 68.5: 14.95
+	Hs
		1393942 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		FUBP3_HUMAN (336-457): 3.82e-12: 70.4: 24.59
+	Hs
		1146803 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		PCBP1_HUMAN (7-111): 7.46e-12: 68.5: 14.95
+	Hs
		1370837 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		FUBP2_HUMAN (238-460): 3.96e-10: 64.2: 17.09
+	Hs
		135336 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		IF2B3_HUMAN (193-461): 4.23e-09: 60.7: 13.99