HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 376
+	Hs
		241247 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		241352 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		241357 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		241360 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		241315 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Mm
		953293 PRKN_MOUSE (1-465): 4.89e-131: 388: 83.66		ACTB_MOUSE (3-376): 0: 595: 91.71
+	Mm
		996586 PRKN_MOUSE (1-465): 4.89e-131: 388: 83.66		ACTS_MOUSE (2-376): 0: 588: 87.47
+	Hs
		995682 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		953078 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		995803 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Sc
		509679 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		ACT_YEAST (1-376): 0: 583: 82.98