Protein: PRKN
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase)

Gene: PRKN
Organism: Mus musculus
Interactions: 41
UniProt ID: Q9WVS6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
GO:0000422 - autophagy of mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1224168

SH3G2
Endophilin-A1

1

18

Small-scale

0.770

High

1060154

BAX
Apoptosis regulator BAX

1

9

Small-scale

0.724

High

996057

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1455950

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

18

Small-scale

0.647

High

267280

CSKP
Peripheral plasma membrane protein CASK

1

20

Small-scale

0.618

High

362457

ABL1
Tyrosine-protein kinase ABL1

1

11

Small-scale

0.618

High

522181

BCL2
Apoptosis regulator Bcl-2

1

9

Small-scale

0.618

High

867765

MK14
Mitogen-activated protein kinase 14

1

11

Small-scale

0.618

High

1224160

SH3G1
Endophilin-A2

1

19

Small-scale

0.618

High

1224171

SH3G3
Endophilin-A3

1

18

Small-scale

0.618

High

1296682

FBXW8
F-box/WD repeat-containing protein 8

1

19

Small-scale

0.618

High

1408886

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

Small-scale

0.618

High

1424419

RBP2
E3 SUMO-protein ligase RanBP2

1

7

Small-scale

0.618

High

1490187

HDAC6
Protein deacetylase HDAC6

1

16

Small-scale

0.618

High

1281977

MFN2
Mitofusin-2

2

6

Small-scale

0.611

High

312673

BECN1
Beclin-1

2

3

Small-scale

0.584

High

1298005

Q8C1W2
Galectin

2

5

Small-scale

0.584

High

92780

D3Z656
Synaptojanin-1

1

10

Small-scale

0.561

High

1341599

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

13

Small-scale

0.561

High

839863

EPS15
Epidermal growth factor receptor substrate 15

1

20

Small-scale

0.501

High

1235112

CHSS2
Chondroitin sulfate synthase 2

1

2

Small-scale

0.494

High

59338

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

20

Small-scale

0.479

High

148111

PRDX6
Peroxiredoxin-6

1

17

Small-scale

0.479

High

204303

PHB2
Prohibitin-2

1

10

Small-scale

0.479

High

382524

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

661126

IRF8
Interferon regulatory factor 8

1

5

High-throughput

0.479

High

811310

GRIK2
Glutamate receptor ionotropic, kainate 2

1

11

Small-scale

0.479

High

813548

CDN1A
Cyclin-dependent kinase inhibitor 1

1

10

Small-scale

0.479

High

827681

SYT4
Synaptotagmin-4

1

9

Small-scale

0.479

High

890931

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

932616

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

7

Small-scale

0.479

High

953293

ACTB
Actin, cytoplasmic 1

1

15

Small-scale

0.479

High

996586

ACTS
Actin, alpha skeletal muscle

1

14

Small-scale

0.479

High

999289

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

1189717

ZN746
Zinc finger protein 746

1

13

Small-scale

0.479

High

1221582

ZBT17
Zinc finger and BTB domain-containing protein 17

1

11

Small-scale

0.479

High

1223262

HS71A
Heat shock 70 kDa protein 1A

1

13

Small-scale

0.479

High

1424121

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

9

Small-scale

0.479

High

148213

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

9

High-throughput

0.445

High

236661

IKBE
NF-kappa-B inhibitor epsilon

1

20

High-throughput

0.445

High

1455969

B9D1
B9 domain-containing protein 1

1

1

Small-scale

0.445

High


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Last updated: 11Aug2025