HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: SLAF1 (Q13291)
Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
Gene: SLAMF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	11313386, 11806999, 11477068, 15841490, 19150402, 20231852, 10607564, 11823424, 12545174, 9774102, 16983070, 14674764, 10549287, 11389028, 12225753
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti bait coimmunoprecipitation, peptide array, fluorescence polarization spectroscopy, nuclear magnetic resonance, x-ray crystallography, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 335
+	Hs
		1030743 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF1_HUMAN (1-335): 3.45e-80: 249: 100.00
+	Hs
		454828 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		SLAF1_HUMAN (1-335): 3.45e-80: 249: 100.00
+	Mm
		1322348 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77
+	Hs
		1271567 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF7_HUMAN (5-334): 1e-59: 196: 19.46
+	Hs
		789096 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SLAF5_HUMAN (15-334): 6.3e-54: 181: 21.21
+	Hs
		433317 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		CXAR_HUMAN (10-334): 1.04e-51: 176: 13.68
+	Hs
		433691 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CXAR_HUMAN (10-334): 1.04e-51: 176: 13.68
+	Hs
		507897 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12
+	Hs
		433229 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12
+	Hs
		523136 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		1271565 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		411547 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD2_HUMAN (14-323): 1.49e-47: 165: 18.79
+	Hs
		507818 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12
+	Hs
		523015 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CEA21_HUMAN (7-295): 5.06e-49: 167: 17.51
+	Hs
		411818 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04
+	Hs
		1271566 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		LY9_HUMAN (10-246): 1.54e-43: 160: 22.54
+	Hs
		411561 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD48_HUMAN (35-256): 1.1e-43: 152: 23.66
+	Hs
		433573 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29
+	Hs
		522773 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29
+	Hs
		522764 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD33_HUMAN (102-211): 9.8e-11: 64.1: 23.93