Protein: SYTC2
Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3)

Gene: SYTC2, TARS3
Organism: Homo sapiens
Interactions: 58
UniProt ID: A2RTX5

Gene Ontology (top 5):
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

60490

SYTC
Threonine--tRNA ligase 1, cytoplasmic

4

14

High-throughput

0.903

High

60521

SYTM
Threonine--tRNA ligase, mitochondrial

2

14

High-throughput

0.783

High

60478

SDCB1
Syntenin-1

4

1

High-throughput

0.691

High

60477

B2RDX5
threonine--tRNA ligase

1

14

High-throughput

0.665

High

60500

RASF7
Ras association domain-containing protein 7

3

0

High-throughput

0.638

High

60503

NMI
N-myc-interactor

3

0

High-throughput

0.638

High

60482

IF4E2
Eukaryotic translation initiation factor 4E type 2

2

1

High-throughput

0.628

High

60493

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

1

High-throughput

0.628

High

60495

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

2

High-throughput

0.628

High

60497

SYRC
Arginine--tRNA ligase, cytoplasmic

2

3

High-throughput

0.628

High

60502

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

5

High-throughput

0.628

High

60504

SYK
Lysine--tRNA ligase

2

10

High-throughput

0.628

High

60523

ING2
Inhibitor of growth protein 2

2

2

High-throughput

0.628

High

60525

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

7

High-throughput

0.628

High

60530

SYLC
Leucine--tRNA ligase, cytoplasmic

2

12

High-throughput

0.628

High

60520

FERM1
Fermitin family homolog 1

2

0

High-throughput

0.602

High

60522

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

60479

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.580

High

60488

ATF4
Cyclic AMP-dependent transcription factor ATF-4

2

0

High-throughput

0.580

High

60519

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

0

High-throughput

0.580

High

60514

PPL13
Placental protein 13-like

2

2

High-throughput

0.553

High

60483

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.536

High

60492

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.536

High

60494

SYQ
Glutamine--tRNA ligase

1

7

High-throughput

0.536

High

60496

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.536

High

60508

C102B
Coiled-coil domain-containing protein 102B

1

2

High-throughput

0.536

High

60510

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

60511

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.536

High

60517

AURKB
Aurora kinase B

1

1

High-throughput

0.536

High

60526

ABCF3
ATP-binding cassette sub-family F member 3

1

5

High-throughput

0.536

High

60501

Q05BL1
TP53BP2 protein

1

2

High-throughput

0.515

High

60486

MYH7
Myosin-7

1

0

High-throughput

0.513

High

60487

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.513

High

60499

SYJ2B
Synaptojanin-2-binding protein

1

0

High-throughput

0.513

High

60512

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

60513

CTCFL
Transcriptional repressor CTCFL

1

0

High-throughput

0.513

High

60516

THOC1
THO complex subunit 1

1

0

High-throughput

0.513

High

60528

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.513

High

60481

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.494

High

60489

ITB8
Integrin beta-8

1

1

High-throughput

0.489

High

60491

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

60531

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

60480

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

60509

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

60518

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

60524

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

60533

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.479

High

60534

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

60485

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

60532

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

60484

CO4A1

1

1

High-throughput

0.437

High

60507

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

60498

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.279

Low

60505

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

60527

ETAA1
Ewing's tumor-associated antigen 1

1

0

High-throughput

0.279

Low

60529

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

60506

CL12A
C-type lectin domain family 12 member A

1

0

High-throughput

0.249

Low

60515

LIPH
Lipase member H

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025