HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	27248496, 30804502, 29176719, 32416067, 30554943, 12840145, 18500820, 19766566, 24361270, 24525235
Identification Methods	affinity chromatography technology, x-ray crystallography, unspecified method, pull down, fluorescent resonance energy transfer, classical fluorescence spectroscopy, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 103
+	Hs
		631388 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917299 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Zm
		19319 A0A1D6HCG5_MAIZE (43-242): 1.58e-37: 153: 25.00		A0A1D6IAU4_MAIZE (1-103): 4.97e-53: 163: 98.06
+	Sc
		356614 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356682 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		448934 GCN5_SCHPO (143-461): 4.74e-40: 157: 14.11		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Sc
		356741 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		448927 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Dm
		532730 FSH_DROME (320-483): 8.28e-29: 128: 33.13		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Dm
		950402 Q9V9T4_DROME (254-469): 3.66e-27: 122: 18.52		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Mm
		918262 BRDT_MOUSE (3-387): 7.84e-26: 117: 17.01		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Dm
		950422 NU301_DROME (330-457): 2.51e-24: 113: 30.47		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		917689 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356388 SPT7_YEAST (223-610): 3.64e-27: 122: 12.08		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Dm
		950390 Q4V5A7_DROME (322-503): 1.9e-21: 102: 25.68		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		917688 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356398 BDF1_YEAST (7-303): 2.12e-26: 118: 17.85		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917517 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356752 BDF2_YEAST (274-571): 7.38e-22: 104: 17.16		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		1271442 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		H4G_HUMAN (1-98): 1.04e-38: 126: 84.69