Protein: NUAK1
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)

Gene: NUAK1
Organism: Homo sapiens
Interactions: 91
UniProt ID: O60285

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0002039 - p53 binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244219

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

6

High-throughput

0.802

High

171128

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

6

Small-scale

0.789

High

239285

MYPT2
Protein phosphatase 1 regulatory subunit 12B

2

6

Small-scale

0.789

High

244279

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

6

Small-scale

0.789

High

244211

LATS1
Serine/threonine-protein kinase LATS1

1

16

Small-scale

0.747

High

244288

FBW1B
F-box/WD repeat-containing protein 11

5

7

Small-scale

0.716

High

244271

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

4

8

Small-scale

0.702

High

244291

FBW1A
F-box/WD repeat-containing protein 1A

4

7

Small-scale

0.699

High

244222

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

High-throughput

0.691

High

244224

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

15

High-throughput

0.691

High

244234

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.691

High

244247

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.691

High

244272

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.691

High

244278

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.691

High

244280

TARA
TRIO and F-actin-binding protein

1

9

High-throughput

0.691

High

244286

RAI14
Ankycorbin

1

6

High-throughput

0.691

High

244289

SRRM2
Serine/arginine repetitive matrix protein 2

2

3

High-throughput

0.621

High

244227

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

4

High-throughput

0.618

High

244261

MPRIP
Myosin phosphatase Rho-interacting protein

1

10

High-throughput

0.618

High

244226

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.618

High

244237

PLK1
Serine/threonine-protein kinase PLK1

1

16

Small-scale

0.618

High

244246

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

16

Small-scale

0.618

High

244284

INCE
Inner centromere protein

1

11

High-throughput

0.618

High

244240

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

2

8

Small-scale

0.611

High

244245

1433F
14-3-3 protein eta

2

20

High-throughput

0.611

High

244214

P53
Cellular tumor antigen p53

1

1

Small-scale

0.597

High

244217

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.590

High

244236

RASF2
Ras association domain-containing protein 2

1

0

High-throughput

0.586

High

244228

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.575

High

209162

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

3

High-throughput

0.536

High

244209

UBR5
E3 ubiquitin-protein ligase UBR5

1

13

High-throughput

0.536

High

244210

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

1

High-throughput

0.536

High

244213

ESR1
Estrogen receptor

1

7

High-throughput

0.536

High

244225

MCM3
DNA replication licensing factor MCM3

1

6

High-throughput

0.536

High

244229

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

244230

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.536

High

244231

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.536

High

244235

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.536

High

244243

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.536

High

244249

CKAP5
Cytoskeleton-associated protein 5

1

13

High-throughput

0.536

High

244250

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

6

High-throughput

0.536

High

244251

UBP2L
Ubiquitin-associated protein 2-like

1

1

High-throughput

0.536

High

244252

DOCK1
Dedicator of cytokinesis protein 1

1

9

High-throughput

0.536

High

244255

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

High-throughput

0.536

High

244258

ATD3B
ATPase family AAA domain-containing protein 3B

1

4

High-throughput

0.536

High

244259

CYTSA
Cytospin-A

1

7

High-throughput

0.536

High

244267

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.536

High

244269

DDX1
ATP-dependent RNA helicase DDX1

1

5

High-throughput

0.536

High

244270

ELMO1
Engulfment and cell motility protein 1

1

1

High-throughput

0.536

High

244275

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.536

High

244276

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.536

High

244277

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.536

High

244282

WDR26
WD repeat-containing protein 26

1

3

High-throughput

0.536

High

244283

WDR6
tRNA

1

13

High-throughput

0.536

High

244287

AKA11
A-kinase anchor protein 11

1

1

High-throughput

0.536

High

244290

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.536

High

244216

S10A8
Protein S100-A8

1

3

High-throughput

0.515

High

244218

S10A9
Protein S100-A9

1

3

High-throughput

0.515

High

244253

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

5

High-throughput

0.515

High

244208

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

244238

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

244254

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.513

High

244257

TM201
Transmembrane protein 201

1

0

High-throughput

0.513

High

244265

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

High-throughput

0.513

High

244281

PININ
Pinin

1

0

High-throughput

0.513

High

244215

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

131248

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

2

High-throughput

0.489

High

158739

AP3D1
AP-3 complex subunit delta-1

1

3

High-throughput

0.489

High

244223

SON
Protein SON

1

5

High-throughput

0.489

High

244256

PRC2B
Protein PRRC2B

1

5

High-throughput

0.489

High

244264

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.489

High

244274

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.489

High

244292

E41L3
Band 4.1-like protein 3

1

8

High-throughput

0.489

High

244232

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

Small-scale

0.481

High

244268

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

244220

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

244221

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

244239

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

244241

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.479

High

244242

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

244248

CUL1
Cullin-1

1

3

Small-scale

0.479

High

244233

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

244263

K2C1B
Keratin, type II cytoskeletal 1b

1

2

High-throughput

0.437

High

244244

PRB3
Basic salivary proline-rich protein 3

1

2

High-throughput

0.407

High

244262

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

1

High-throughput

0.407

High

67447

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.279

Low

244260

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

244266

TM102
Transmembrane protein 102

1

0

High-throughput

0.279

Low

244273

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.279

Low

244285

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.279

Low

244212

IGHA2
Immunoglobulin heavy constant alpha 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025