Protein: SIK1
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

Gene: SIK1
Organism: Homo sapiens
Interactions: 65
UniProt ID: P57059

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0002028 - regulation of sodium ion transport
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943659

SIK2
Serine/threonine-protein kinase SIK2

2

18

High-throughput

0.811

High

943668

SIK3
Serine/threonine-protein kinase SIK3

2

16

High-throughput

0.811

High

943658

SLD5
DNA replication complex GINS protein SLD5

6

0

Small-scale

0.708

High

943639

1433E
14-3-3 protein epsilon

4

19

Small-scale

0.683

High

943640

1433Z
14-3-3 protein zeta/delta

3

20

Small-scale

0.681

High

690863

1433T
14-3-3 protein theta

3

20

Small-scale

0.656

High

605615

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

Small-scale

0.647

High

943649

STK11
Serine/threonine-protein kinase STK11

1

19

Small-scale

0.647

High

213878

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

10

Small-scale

0.618

High

717743

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.618

High

728137

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.618

High

943644

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

17

Small-scale

0.618

High

729710

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.611

High

943637

1433G
14-3-3 protein gamma

2

20

Small-scale

0.611

High

943643

1433F
14-3-3 protein eta

2

20

Small-scale

0.611

High

943652

LHX8
LIM/homeobox protein Lhx8

2

1

High-throughput

0.606

High

943665

HDAC5
Histone deacetylase 5

2

10

Small-scale

0.602

High

943666

PSF2
DNA replication complex GINS protein PSF2

2

0

High-throughput

0.602

High

943642

PITX1
Pituitary homeobox 1

2

0

High-throughput

0.580

High

943661

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

0

High-throughput

0.580

High

887878

MCM2
DNA replication licensing factor MCM2

1

3

Small-scale

0.561

High

943655

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

13

Small-scale

0.561

High

943657

RING2
E3 ubiquitin-protein ligase RING2

1

5

Small-scale

0.561

High

130415

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.541

High

809988

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.541

High

424492

PAI2
Plasminogen activator inhibitor 2

1

1

High-throughput

0.536

High

474584

VIME
Vimentin

1

6

High-throughput

0.536

High

502280

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

568954

ANXA8
Annexin A8

1

1

High-throughput

0.536

High

633363

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.536

High

748641

DSG3
Desmoglein-3

1

3

High-throughput

0.536

High

786044

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.536

High

869832

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.536

High

909300

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

2

High-throughput

0.536

High

943636

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

943660

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.518

High

578648

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

728987

ABC3A
DNA dC->dU-editing enzyme APOBEC-3A

1

0

High-throughput

0.513

High

943646

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

943656

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.513

High

529448

TAU
Microtubule-associated protein tau

1

8

Small-scale

0.501

High

210736

KLK10
Kallikrein-10

1

2

High-throughput

0.489

High

483317

CLCB
Clathrin light chain B

1

2

High-throughput

0.489

High

706089

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

172628

XPO1
Exportin-1

1

8

High-throughput

0.479

High

330799

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

686045

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

695063

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.479

High

730472

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

943641

EF1A1
Elongation factor 1-alpha 1

1

4

Small-scale

0.479

High

943653

FBX22
F-box only protein 22

1

1

Small-scale

0.479

High

943654

APBP2
Amyloid protein-binding protein 2

1

1

Small-scale

0.479

High

943662

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

827726

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

943645

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

943650

H2B2E
Histone H2B type 2-E

1

0

Small-scale

0.458

High

943651

CRTC2
CREB-regulated transcription coactivator 2

1

6

Small-scale

0.445

High

635843

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

943638

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

2

0

High-throughput

0.316

High

943647

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

698532

CALX
Calnexin

1

0

High-throughput

0.279

Low

943648

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.279

Low

943663

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.279

Low

943664

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

943667

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025