HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	32416067, 27626385, 36089195
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 136
+	Hs
		244266 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		244592 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		631395 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		631400 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		934782 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952348 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		631374 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		828234 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Sp
		457192 GCN5_SCHPO (143-461): 4.74e-40: 157: 14.11		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Sc
		860437 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		902028 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		902084 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sp
		457186 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Hs
		319165 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		319169 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		319213 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		319242 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	At
		886669 GTE3_ARATH (251-640): 4.07e-33: 136: 17.38		H31_ARATH (1-136): 1.05e-58: 179: 94.85
+	Dm
		356065 FSH_DROME (320-483): 8.28e-29: 128: 33.13		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Sc
		730923 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67