HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 372
+	Hs
		243698 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260758 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260889 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		631613 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		1067170 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		244634 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		244848 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2A1J_HUMAN (1-125): 2.23e-64: 202: 60.94
+	Hs
		243783 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		244795 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2A1H_HUMAN (1-125): 5.02e-64: 201: 60.94
+	Hs
		555299 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		555470 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		631492 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		1067038 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		391554 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		1066979 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Hs
		1067005 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2A2A_HUMAN (1-126): 4.27e-64: 201: 62.02
+	Sc
		392189 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2A1_YEAST (14-125): 3.15e-41: 143: 65.79
+	Sc
		392513 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H2A2_YEAST (14-124): 2.55e-41: 143: 65.77
+	Sc
		392549 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2A2_YEAST (14-124): 2.55e-41: 143: 65.77
+	Sc
		392211 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H2A1_YEAST (14-125): 3.15e-41: 143: 65.79