Protein: DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]

Gene: DNA2
Organism: Homo sapiens
Interactions: 72
UniProt ID: P51530

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000729 - DNA double-strand break processing
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

903087

MMS19
MMS19 nucleotide excision repair protein homolog

4

1

Small-scale

0.694

High

903088

DNJC7
DnaJ homolog subfamily C member 7

4

1

High-throughput

0.691

High

302791

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

3

5

High-throughput

0.667

High

903061

CDR2
Cerebellar degeneration-related protein 2

3

0

High-throughput

0.634

High

903101

NOB1
RNA-binding protein NOB1

3

0

High-throughput

0.634

High

60495

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

2

High-throughput

0.628

High

224096

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

2

3

High-throughput

0.628

High

903072

TEBP
Prostaglandin E synthase 3

2

3

High-throughput

0.628

High

903080

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

6

High-throughput

0.628

High

903081

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.618

High

302045

SEGN
Secretagogin

2

1

High-throughput

0.611

High

903103

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

1

High-throughput

0.611

High

651631

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

0

High-throughput

0.602

High

903077

BORA
Protein aurora borealis

2

0

High-throughput

0.602

High

903091

MSTO1
Protein misato homolog 1

2

0

High-throughput

0.602

High

903099

NRBP
Nuclear receptor-binding protein

2

0

High-throughput

0.602

High

903100

AKA11
A-kinase anchor protein 11

2

0

High-throughput

0.602

High

258807

DNJA2
DnaJ homolog subfamily A member 2

2

3

High-throughput

0.601

High

903065

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.578

High

903104

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.561

High

571399

GLU2B
Glucosidase 2 subunit beta

2

2

High-throughput

0.558

High

903089

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

334160

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

903064

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

903082

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

903093

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

903094

TTC12
Tetratricopeptide repeat protein 12

1

4

High-throughput

0.536

High

903096

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

903102

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.536

High

277450

AVIL
Advillin

1

0

High-throughput

0.513

High

300123

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.513

High

611656

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.513

High

903058

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

903086

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

903098

DBF4A
Protein DBF4 homolog A

1

0

High-throughput

0.513

High

903057

BLM
RecQ-like DNA helicase BLM

1

8

Small-scale

0.501

High

903071

PLEC
Plectin

1

0

High-throughput

0.493

High

873720

GSH0
Glutamate--cysteine ligase regulatory subunit

1

1

High-throughput

0.489

High

174496

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.479

High

291913

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

Small-scale

0.479

High

293391

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

352369

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.479

High

463411

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.479

High

588238

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

694963

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

767733

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

814489

FEN1
Flap endonuclease 1

1

7

Small-scale

0.479

High

903066

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

2

High-throughput

0.479

High

903067

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

903068

CUL3
Cullin-3

1

8

High-throughput

0.479

High

903069

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

903070

CUL4B
Cullin-4B

1

8

High-throughput

0.479

High

903073

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

903079

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

903085

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

903092

FACD2
Fanconi anemia group D2 protein

1

5

Small-scale

0.479

High

903095

BRD7
Bromodomain-containing protein 7

1

6

High-throughput

0.479

High

903060

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.458

High

903063

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.458

High

848764

MAGAA
Melanoma-associated antigen 10

1

2

High-throughput

0.445

High

903059

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

5

High-throughput

0.445

High

679315

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

903083

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.426

High

903097

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

7

High-throughput

0.407

High

399672

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

0

High-throughput

0.328

High

903078

FAT4
Protocadherin Fat 4

2

0

High-throughput

0.328

High

903076

WAC2A
WASH complex subunit 2A

2

0

High-throughput

0.313

High

903075

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

903090

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.279

Low

903062

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.249

Low

903074

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

903084

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025