HitPredict

Interactor 1: TBL1X (O60907)
F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)
Gene: TBL1X

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 974
+	Hs
		1162302 TBL1R_HUMAN (52-577): 1.43e-158: 465: 84.25		WDR59_HUMAN (1-974): 0: 805: 100.00
+	Hs
		903313 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		WDR59_HUMAN (1-974): 0: 805: 100.00
+	Hs
		245633 TBL1X_HUMAN (1-577): 0: 532: 100.00		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Hs
		792949 LIS1_HUMAN (51-493): 5.94e-96: 300: 17.74		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Sc
		630844 NLE1_YEAST (152-490): 1.29e-75: 250: 20.05		NLE1_YEAST (144-503): 1.94e-46: 176: 13.41
+	Hs
		903077 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Mm
		925836 LIS1_MOUSE (51-493): 4.13e-96: 301: 17.74		LIS1_MOUSE (278-527): 1.05e-16: 85.6: 8.00
+	Hs
		792935 LIS1_HUMAN (51-493): 5.94e-96: 300: 17.74		LIS1_HUMAN (278-527): 1.09e-16: 85.6: 8.00
+	Hs
		903349 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		WDR5B_HUMAN (180-476): 5.68e-43: 161: 13.40
+	Hs
		1309163 TBL1Y_HUMAN (309-577): 1.63e-61: 213: 20.41		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Ce
		954090 LIS1_CAEEL (50-493): 4.56e-89: 282: 16.70		LIN53_CAEEL (104-371): 8.15e-17: 86.1: 19.07
+	Hs
		196984 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85
+	Hs
		903418 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93
+	Hs
		903471 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		1202778 WDR5B_HUMAN (363-577): 5.45e-64: 214: 26.15		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		903551 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		NLE1_HUMAN (3-88): 1.27e-17: 89.1: 7.78
+	Hs
		903171 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		903428 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		SNR40_HUMAN (268-503): 1.87e-17: 87.2: 9.09