Protein: PRDM1
PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)

Gene: PRDM1
Organism: Homo sapiens
Interactions: 114
UniProt ID: O75626

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001763 - morphogenesis of a branching structure
GO:0001822 - kidney development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

289190

IKZF3
Zinc finger protein Aiolos

1

17

Small-scale

0.724

High

289164

HDAC2
Histone deacetylase 2

5

6

Small-scale

0.713

High

137368

BT3A3
Butyrophilin subfamily 3 member A3

1

18

Small-scale

0.665

High

289168

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

2

Small-scale

0.640

High

289113

SRC
Proto-oncogene tyrosine-protein kinase Src

2

1

High-throughput

0.628

High

289130

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

2

High-throughput

0.628

High

289147

UBE4A
Ubiquitin conjugation factor E4 A

2

8

High-throughput

0.628

High

289099

PRDM1
PR domain zinc finger protein 1

1

17

Small-scale

0.618

High

289109

GLI3
Transcriptional activator GLI3

1

18

Small-scale

0.618

High

289142

RN5A
2-5A-dependent ribonuclease

1

1

Small-scale

0.618

High

289157

ZSCA2
Zinc finger and SCAN domain-containing protein 2

1

20

Small-scale

0.618

High

289159

ZFHX4
Zinc finger homeobox protein 4

1

18

High-throughput

0.618

High

289192

ZBT32
Zinc finger and BTB domain-containing protein 32

1

16

Small-scale

0.618

High

289120

C2TA
MHC class II transactivator

2

3

Small-scale

0.601

High

289137

TLE1
Transducin-like enhancer protein 1

2

6

Small-scale

0.595

High

289150

NFIX
Nuclear factor 1 X-type

2

20

Small-scale

0.595

High

162408

ANM5
Protein arginine N-methyltransferase 5

2

1

Small-scale

0.584

High

289146

HDAC1
Histone deacetylase 1

2

6

Small-scale

0.584

High

289148

DPYL3
Dihydropyrimidinase-related protein 3

2

1

High-throughput

0.574

High

289111

CH60
60 kDa heat shock protein, mitochondrial

2

0

Small-scale

0.569

High

289100

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

Small-scale

0.564

High

246351

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.561

High

289107

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

289172

FOXP1
Forkhead box protein P1

2

0

Small-scale

0.559

High

289114

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

289145

DLG1
Disks large homolog 1

1

1

High-throughput

0.536

High

289160

FANCM
Fanconi anemia group M protein

1

6

High-throughput

0.536

High

289196

TIM9
Mitochondrial import inner membrane translocase subunit Tim9

1

1

High-throughput

0.536

High

289128

F10A1
Hsc70-interacting protein

1

13

High-throughput

0.515

High

289132

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

3

Small-scale

0.515

High

289134

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.515

High

289144

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

289174

SP110
Sp110 nuclear body protein

1

20

Small-scale

0.515

High

289193

TLN1
Talin-1

1

2

Small-scale

0.515

High

289133

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.513

High

289153

KIZ
Centrosomal protein kizuna

1

0

High-throughput

0.513

High

289131

ATX1
Ataxin-1

1

1

High-throughput

0.508

High

289123

HNF1B
Hepatocyte nuclear factor 1-beta

1

5

High-throughput

0.501

High

289136

H11
Histone H1.1

1

15

Small-scale

0.501

High

289138

TLE2
Transducin-like enhancer protein 2

1

5

Small-scale

0.501

High

289156

H32
Histone H3.2

1

10

Small-scale

0.501

High

289154

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.500

High

166104

AIM2
Interferon-inducible protein AIM2

1

0

Small-scale

0.493

High

289162

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

1

0

Small-scale

0.493

High

289200

NS1BP
Influenza virus NS1A-binding protein

1

0

Small-scale

0.493

High

289129

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

289110

RRAS
Ras-related protein R-Ras

1

1

High-throughput

0.489

High

142762

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

174290

ZN609
Zinc finger protein 609

1

2

High-throughput

0.479

High

278190

NCOR1
Nuclear receptor corepressor 1

1

9

High-throughput

0.479

High

289103

GCR
Glucocorticoid receptor

1

19

Small-scale

0.479

High

289105

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

289106

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

289108

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

289112

BIP
Endoplasmic reticulum chaperone BiP

1

5

Small-scale

0.479

High

289115

CEBPB
CCAAT/enhancer-binding protein beta

1

8

Small-scale

0.479

High

289116

SP100
Nuclear autoantigen Sp-100

1

9

Small-scale

0.479

High

289117

RBTN2
Rhombotin-2

1

9

Small-scale

0.479

High

289119

PSB8
Proteasome subunit beta type-8

1

1

Small-scale

0.479

High

289121

H2B1B
Histone H2B type 1-B

1

5

High-throughput

0.479

High

289124

HSPA9
Stress-70 protein, mitochondrial

1

7

Small-scale

0.479

High

289125

PSB10
Proteasome subunit beta type-10

1

1

Small-scale

0.479

High

289126

STAT6
Signal transducer and activator of transcription 6

1

1

Small-scale

0.479

High

289135

GTF2I
General transcription factor II-I

1

2

Small-scale

0.479

High

289139

TLE3
Transducin-like enhancer protein 3

1

6

High-throughput

0.479

High

289140

TLE4
Transducin-like enhancer protein 4

1

6

High-throughput

0.479

High

289143

TLE5
TLE family member 5

1

5

High-throughput

0.479

High

289151

IRF4
Interferon regulatory factor 4

1

1

Small-scale

0.479

High

289152

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.479

High

289155

BCOR
BCL-6 corepressor

1

5

High-throughput

0.479

High

289158

PCGF5
Polycomb group RING finger protein 5

1

3

High-throughput

0.479

High

289161

KDM2B
Lysine-specific demethylase 2B

1

1

High-throughput

0.479

High

289166

TRI44
Tripartite motif-containing protein 44

1

20

Small-scale

0.479

High

289167

ZN503
Zinc finger protein 503

1

1

High-throughput

0.479

High

289169

CIC
Protein capicua homolog

1

8

High-throughput

0.479

High

289171

PCGF1
Polycomb group RING finger protein 1

1

14

High-throughput

0.479

High

289173

ZN703
Zinc finger protein 703

1

2

High-throughput

0.479

High

289177

HM20A
High mobility group protein 20A

1

9

High-throughput

0.479

High

289179

TF7L2
Transcription factor 7-like 2

1

9

High-throughput

0.479

High

289181

ANM7
Protein arginine N-methyltransferase 7

1

2

Small-scale

0.479

High

289183

SENP1
Sentrin-specific protease 1

1

1

Small-scale

0.479

High

289184

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

5

High-throughput

0.479

High

289185

RCOR3
REST corepressor 3

1

4

High-throughput

0.479

High

289187

TRPS1
Zinc finger transcription factor Trps1

1

5

High-throughput

0.479

High

289188

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

289191

ZN608
Zinc finger protein 608

1

2

High-throughput

0.479

High

289194

ARIP4
Helicase ARIP4

1

12

High-throughput

0.479

High

289198

NCOR2
Nuclear receptor corepressor 2

1

4

High-throughput

0.479

High

289199

DUS10
Dual specificity protein phosphatase 10

1

2

Small-scale

0.479

High

160669

TOR1A
Torsin-1A

1

2

High-throughput

0.470

High

261355

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.458

High

289102

IFNB
Interferon beta

1

0

Small-scale

0.458

High

289127

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

289141

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

289149

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.458

High

289163

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.458

High

289175

SPC25
Kinetochore protein Spc25

1

0

Small-scale

0.458

High

289178

FANCF
Fanconi anemia group F protein

1

0

Small-scale

0.458

High

289180

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

289182

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

Small-scale

0.458

High

289186

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.458

High

289189

RALY
RNA-binding protein Raly

1

0

Small-scale

0.458

High

289197

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.458

High

289122

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

20

High-throughput

0.457

High

163212

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

7

Small-scale

0.437

High

193658

TPSN
Tapasin

1

1

Small-scale

0.437

High

289118

ITB7
Integrin beta-7

1

16

Small-scale

0.437

High

289101

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.268

Low

289170

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.261

Low

289195

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

1

0

High-throughput

0.261

Low

289104

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.249

Low

289165

TSLP
Thymic stromal lymphopoietin

1

0

Small-scale

0.249

Low

289176

FBSL
Fibrosin-1-like protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025