Protein: ZEB2
Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)

Gene: ZEB2
Organism: Homo sapiens
Interactions: 96
UniProt ID: O60315

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

245623

CTBP1
C-terminal-binding protein 1

9

8

Small-scale

0.755

High

245606

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

245632

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.724

High

245624

HDAC1
Histone deacetylase 1

5

10

Small-scale

0.712

High

245587

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

245610

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.691

High

245640

HDAC2
Histone deacetylase 2

4

10

Small-scale

0.687

High

245622

MTA1
Metastasis-associated protein MTA1

3

5

Small-scale

0.684

High

245616

RBBP4
Histone-binding protein RBBP4

4

3

Small-scale

0.683

High

245570

MTA2
Metastasis-associated protein MTA2

3

5

Small-scale

0.667

High

245575

A4
Amyloid-beta precursor protein

3

16

High-throughput

0.658

High

216861

KLF4
Krueppel-like factor 4

1

19

High-throughput

0.618

High

245573

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

245580

EGR2
E3 SUMO-protein ligase EGR2

1

20

High-throughput

0.618

High

245637

SP7
Transcription factor Sp7

1

20

High-throughput

0.618

High

245648

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.618

High

245652

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

245612

SMAD3
Mothers against decapentaplegic homolog 3

2

15

Small-scale

0.600

High

245630

SMAD1
Mothers against decapentaplegic homolog 1

2

15

Small-scale

0.600

High

245576

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

245601

CEBPA
CCAAT/enhancer-binding protein alpha

2

8

Small-scale

0.584

High

245627

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

129618

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.578

High

245639

ZN516
Zinc finger protein 516

1

19

Small-scale

0.575

High

245645

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

Small-scale

0.568

High

245574

MBD3
Methyl-CpG-binding domain protein 3

2

0

Small-scale

0.563

High

245577

FBSP1
F-box/SPRY domain-containing protein 1

1

7

Small-scale

0.561

High

245600

DGKG
Diacylglycerol kinase gamma

1

1

Small-scale

0.561

High

245653

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

8

Small-scale

0.561

High

245599

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.536

High

245604

CTBP2
C-terminal-binding protein 2

1

8

High-throughput

0.536

High

245628

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.536

High

245635

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

181836

SMAD9
Mothers against decapentaplegic homolog 9

1

15

High-throughput

0.508

High

245629

SMAD2
Mothers against decapentaplegic homolog 2

1

15

High-throughput

0.508

High

245608

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.501

High

130317

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.479

High

142740

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

181478

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

188119

HDAC3
Histone deacetylase 3

1

10

Small-scale

0.479

High

190752

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

209921

CRX
Cone-rod homeobox protein

1

11

High-throughput

0.479

High

245568

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

245569

BAF
Barrier-to-autointegration factor

1

1

High-throughput

0.479

High

245571

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

245572

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

245579

MYB
Transcriptional activator Myb

1

2

High-throughput

0.479

High

245581

CADH1
Cadherin-1

1

2

Small-scale

0.479

High

245582

HXB2
Homeobox protein Hox-B2

1

11

High-throughput

0.479

High

245583

MYOD1
Myoblast determination protein 1

1

5

High-throughput

0.479

High

245584

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

245585

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

245588

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

245590

PAX6
Paired box protein Pax-6

1

7

High-throughput

0.479

High

245591

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

245592

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

245593

TLX1
T-cell leukemia homeobox protein 1

1

11

High-throughput

0.479

High

245594

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

245595

HNF1B
Hepatocyte nuclear factor 1-beta

1

13

High-throughput

0.479

High

245596

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

High-throughput

0.479

High

245597

ELK3
ETS domain-containing protein Elk-3

1

5

High-throughput

0.479

High

245598

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

245602

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.479

High

245603

HDAC4
Histone deacetylase 4

1

11

Small-scale

0.479

High

245605

GSC
Homeobox protein goosecoid

1

16

High-throughput

0.479

High

245609

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

245611

H31
Histone H3.1

1

12

High-throughput

0.479

High

245613

H33
Histone H3.3

1

12

High-throughput

0.479

High

245614

HME1
Homeobox protein engrailed-1

1

5

High-throughput

0.479

High

245615

PAX8
Paired box protein Pax-8

1

7

High-throughput

0.479

High

245617

EP300
Histone acetyltransferase p300

1

7

Small-scale

0.479

High

245618

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

245620

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.479

High

245621

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

1

High-throughput

0.479

High

245625

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

245626

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

245631

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

245633

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.479

High

245636

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

245641

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

245642

PF21A
PHD finger protein 21A

1

18

High-throughput

0.479

High

245646

FEV
Protein FEV

1

5

High-throughput

0.479

High

245647

SOX7
Transcription factor SOX-7

1

11

High-throughput

0.479

High

245649

VSX1
Visual system homeobox 1

1

8

High-throughput

0.479

High

245650

LHX3
LIM/homeobox protein Lhx3

1

7

High-throughput

0.479

High

245651

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

245578

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

245607

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

245634

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

245589

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

Small-scale

0.445

High

245619

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

Small-scale

0.445

High

245643

MBD6
Methyl-CpG-binding domain protein 6

1

2

Small-scale

0.445

High

245644

MTBP
Mdm2-binding protein

1

0

Small-scale

0.426

High

65402

PGPIL
Pyroglutamyl-peptidase 1-like protein

1

0

High-throughput

0.249

Low

245586

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.249

Low

245638

ATS16
A disintegrin and metalloproteinase with thrombospondin motifs 16

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025