HitPredict

Interactor 1: CATL2 (O60911)
Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V)
Gene: CTSV

Interactor 2: CATL1 (P07711)
Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
Gene: CTSL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Inhibitor_I29~Inhibitor_I29, Inhibitor_I29~Peptidase_C1, Peptidase_C1~Peptidase_C1
Common GO terms	GO:0004197 - cysteine-type endopeptidase activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006955 - immune response GO:0008234 - cysteine-type peptidase activity and 5 others more... GO:0008656 - cysteine-type endopeptidase activator activity involved in apoptotic process GO:0019886 - antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0043202 - lysosomal lumen GO:0051603 - proteolysis involved in protein catabolic process GO:2001235 - positive regulation of apoptotic signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	334
Hs

1	333

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024