Protein: CADH5
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)

Gene: CADH5, CDH5
Organism: Homo sapiens
Interactions: 109
UniProt ID: P33151

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0001886 - endothelial cell morphogenesis
GO:0001955 - blood vessel maturation
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

749752

CTNB1
Catenin beta-1

13

20

Small-scale

0.979

High

254067

CTND1
Catenin delta-1

4

20

Small-scale

0.895

High

749802

PKP4
Plakophilin-4

3

20

Small-scale

0.863

High

577641

PLAK
Junction plakoglobin

3

20

Small-scale

0.847

High

125881

ARVC
Splicing regulator ARVCF

2

20

High-throughput

0.811

High

749751

CTNA1
Catenin alpha-1

5

20

Small-scale

0.714

High

168821

PLD2
Phospholipase D2

3

2

Small-scale

0.667

High

749753

VGFR2
Vascular endothelial growth factor receptor 2

3

9

Small-scale

0.643

High

165015

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

1

High-throughput

0.628

High

294776

CAN15
Calpain-15

2

2

High-throughput

0.628

High

331718

MTMR5
Myotubularin-related protein 5

2

2

High-throughput

0.628

High

617275

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

2

5

High-throughput

0.628

High

643347

OSBP1
Oxysterol-binding protein 1

2

2

High-throughput

0.628

High

684475

CTNA2
Catenin alpha-2

2

20

High-throughput

0.628

High

749757

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

2

High-throughput

0.628

High

749758

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

3

High-throughput

0.628

High

749766

SRBP2
Sterol regulatory element-binding protein 2

2

8

High-throughput

0.628

High

749767

PLD1
Phospholipase D1

2

2

High-throughput

0.628

High

749770

DAG1
Dystroglycan 1

2

7

High-throughput

0.628

High

749771

KEAP1
Kelch-like ECH-associated protein 1

2

5

High-throughput

0.628

High

749773

LTBP1
Latent-transforming growth factor beta-binding protein 1

2

8

High-throughput

0.628

High

749776

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

2

2

High-throughput

0.628

High

749783

TMTC3
Protein O-mannosyl-transferase TMTC3

2

9

High-throughput

0.628

High

749784

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

High-throughput

0.628

High

749787

WDR75
WD repeat-containing protein 75

2

3

High-throughput

0.628

High

749788

PLPL6
Patatin-like phospholipase domain-containing protein 6

2

6

High-throughput

0.628

High

749789

MICU2
Calcium uptake protein 2, mitochondrial

2

2

High-throughput

0.628

High

749790

ASPM
Abnormal spindle-like microcephaly-associated protein

2

14

High-throughput

0.628

High

749792

MACOI
Macoilin

2

8

High-throughput

0.628

High

749794

TIP
T-cell immunomodulatory protein

2

3

High-throughput

0.628

High

749797

PTPRU
Receptor-type tyrosine-protein phosphatase U

2

20

High-throughput

0.628

High

749800

P121A
Nuclear envelope pore membrane protein POM 121

2

8

High-throughput

0.628

High

749801

DNJC1
DnaJ homolog subfamily C member 1

2

3

High-throughput

0.628

High

749804

MICU1
Calcium uptake protein 1, mitochondrial

2

2

High-throughput

0.628

High

749812

MYO5C
Unconventional myosin-Vc

2

2

High-throughput

0.628

High

749813

ST7
Suppressor of tumorigenicity 7 protein

2

7

High-throughput

0.628

High

749817

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

2

3

High-throughput

0.628

High

749821

KDIS
Kinase D-interacting substrate of 220 kDa

2

2

High-throughput

0.628

High

749825

MYO5A
Unconventional myosin-Va

2

4

High-throughput

0.628

High

342429

RPP29
Ribonuclease P protein subunit p29

2

0

High-throughput

0.602

High

749756

TNFL9
Tumor necrosis factor ligand superfamily member 9

2

0

High-throughput

0.602

High

749799

MCRS1
Microspherule protein 1

2

0

High-throughput

0.602

High

749809

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

2

0

High-throughput

0.602

High

749822

VANG2
Vang-like protein 2

2

0

High-throughput

0.602

High

749827

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

0

High-throughput

0.602

High

362854

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.584

High

711251

SHC1
SHC-transforming protein 1

1

10

Small-scale

0.578

High

337691

SGPL1
Sphingosine-1-phosphate lyase 1

2

2

High-throughput

0.574

High

749754

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

2

High-throughput

0.574

High

749774

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

1

High-throughput

0.574

High

749786

CEP57
Centrosomal protein of 57 kDa

2

1

High-throughput

0.574

High

749823

SCML1
Sex comb on midleg-like protein 1

2

1

High-throughput

0.574

High

749824

EXOG
Nuclease EXOG, mitochondrial

2

1

High-throughput

0.574

High

749826

TBL2
Transducin beta-like protein 2

2

5

High-throughput

0.574

High

557133

SRC
Proto-oncogene tyrosine-protein kinase Src

2

7

Small-scale

0.571

High

658809

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

Small-scale

0.561

High

227810

MYO1B
Unconventional myosin-Ib

1

6

High-throughput

0.536

High

289440

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

2

High-throughput

0.536

High

318276

MYO1D
Unconventional myosin-Id

1

6

High-throughput

0.536

High

339946

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

1

High-throughput

0.536

High

749750

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.536

High

749761

RL23
Large ribosomal subunit protein uL14

1

13

High-throughput

0.536

High

749768

MYO9B
Unconventional myosin-IXb

1

5

High-throughput

0.536

High

749772

KCJ11
ATP-sensitive inward rectifier potassium channel 11

1

2

High-throughput

0.536

High

749777

SGCB
Beta-sarcoglycan

1

4

High-throughput

0.536

High

749793

PDZD8
PDZ domain-containing protein 8

1

4

High-throughput

0.536

High

749795

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

1

High-throughput

0.536

High

749807

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.536

High

749810

AT131
Endoplasmic reticulum transmembrane helix translocase

1

7

High-throughput

0.536

High

749815

UFSP2
Ufm1-specific protease 2

1

2

High-throughput

0.536

High

749820

TM59L
Transmembrane protein 59-like

1

1

High-throughput

0.536

High

749796

PARD3
Partitioning defective 3 homolog

1

11

Small-scale

0.534

High

749811

PAR6A
Partitioning defective 6 homolog alpha

1

2

Small-scale

0.534

High

60301

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.513

High

219801

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.513

High

749785

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.513

High

749808

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

657887

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

Small-scale

0.505

High

749805

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.501

High

749779

CEP78
Centrosomal protein of 78 kDa

1

4

High-throughput

0.489

High

749782

PKN3
Serine/threonine-protein kinase N3

1

4

High-throughput

0.489

High

749816

TM39A
Transmembrane protein 39A

1

2

High-throughput

0.489

High

387705

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

0

Small-scale

0.480

High

245786

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

2

Small-scale

0.479

High

349829

SNAI1
Zinc finger protein SNAI1

1

5

Small-scale

0.479

High

474510

VIME
Vimentin

1

2

Small-scale

0.479

High

587571

DESP
Desmoplakin

1

10

Small-scale

0.479

High

603182

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.479

High

612893

EGR1
Early growth response protein 1

1

3

Small-scale

0.479

High

613304

VINC
Vinculin

1

20

Small-scale

0.479

High

749755

P2RY2
P2Y purinoceptor 2

1

3

Small-scale

0.479

High

749759

AFAD
Afadin

1

7

Small-scale

0.479

High

749763

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.479

High

749764

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.479

High

749769

BMPR2
Bone morphogenetic protein receptor type-2

1

9

Small-scale

0.479

High

749775

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

20

Small-scale

0.479

High

749806

PAR6G
Partitioning defective 6 homolog gamma

1

3

Small-scale

0.479

High

749803

P2RX4
P2X purinoceptor 4

1

0

Small-scale

0.458

High

749814

CNBP1
Beta-catenin-interacting protein 1

1

0

Small-scale

0.458

High

749765

ZO1
Tight junction protein 1

1

9

Small-scale

0.445

High

749762

HTRA4
Serine protease HTRA4

1

1

Small-scale

0.407

High

749781

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

749778

TIGD5
Tigger transposable element-derived protein 5

2

0

High-throughput

0.328

High

749780

ZMYM1
Zinc finger MYM-type protein 1

2

0

High-throughput

0.328

High

749791

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.328

High

749798

SARAF
Store-operated calcium entry-associated regulatory factor

2

0

High-throughput

0.328

High

749818

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.328

High

749819

ZNHI2
Zinc finger HIT domain-containing protein 2

2

0

High-throughput

0.328

High

749760

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025