HitPredict

Interactor 1: NBN (O60934)
Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1)
Gene: NBN

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 25939603, 19244116, 25184681, 25659039, 10783165, 11504724, 29656893, 12124328, 18763866, 18171670
Identification Methods affinity chromatography technology, biochemical, proximity labelling technology
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT
Common GO terms GO:0000724 - double-strand break repair via homologous recombination
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006302 - double-strand break repair
and 6 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 754
Hs

1 1863
+ Hs
+ Xl
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024