HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: Q91YX7 (Q91YX7)
RAS p21 protein activator 1
Gene: Rasa1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.80	0.679

Property	Details
Experiments	20697350, 10428862
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 813
+	Mm
		956523 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		Q91YX7_MOUSE (1-813): 0: 659: 100.00
+	Mm
		93301 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		E9PYG6_MOUSE (91-296): 6.82e-19: 94: 18.57
+	Mm
		956520 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		924816 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Mm
		1141171 DOK3_MOUSE (6-389): 1.3e-103: 315: 32.23		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		924665 DOK3_HUMAN (6-389): 6.65e-101: 310: 32.30		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Hs
		235043 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		RASA1_HUMAN (87-296): 1.11e-18: 93.6: 18.69
+	Rn
		724631 IRS1_RAT (4-375): 5.81e-91: 300: 16.24		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Mm
		724599 IRS1_MOUSE (4-375): 3.64e-90: 297: 16.24		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		724527 IRS1_HUMAN (4-375): 4.22e-89: 294: 16.03		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Hs
		151763 IRS4_HUMAN (4-392): 7.12e-83: 277: 16.01		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Mm
		946348 IRS2_MOUSE (15-348): 9.5e-76: 257: 16.76		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		924983 IRS2_HUMAN (15-348): 2.09e-75: 257: 16.89		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Rn
		94388 F1MAL5_RAT (15-348): 1.6e-74: 254: 15.68		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Mm
		93305 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		E9PYG6_MOUSE (91-296): 6.82e-19: 94: 18.57
+	Hs
		596429 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		RASA1_HUMAN (87-296): 1.11e-18: 93.6: 18.69
+	Rn
		842411 DOK1_RAT (6-394): 7.16e-109: 330: 34.66		RASA1_RAT (91-296): 1.1e-18: 93.6: 18.57
+	Hs
		924725 FRS2_HUMAN (143-403): 8.28e-64: 214: 19.39		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Rn
		88884 D4A244_RAT (143-403): 9.44e-63: 212: 19.73		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Mm
		1141149 FRS2_MOUSE (143-403): 2.91e-62: 210: 19.39		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86