HitPredict

Interactor 1: RPN2 (O74762)
26S proteasome regulatory subunit rpn2
Gene: RPN2

Interactor 2: PRS4 (P36612)
26S proteasome regulatory subunit 4 homolog (Protein mts2)
Gene: mts2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24938783, 22307589
Identification Methods	cross-linking study, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 965 Sp			1 448
+	Hs
		798739 PSMD1_HUMAN (11-939): 0: 1140: 43.04		PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47
+	At
		221383 PSD1A_ARATH (9-959): 0: 1199: 43.66		PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66
+	At
		1341469 PSD1B_ARATH (9-959): 0: 1176: 42.76		PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66
+	Hs
		693 A0A087WW66_HUMAN (11-939): 0: 1052: 40.85		PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47
+	Hs
		906907 PSMD1_HUMAN (11-939): 0: 1140: 43.04		PRS4_HUMAN (50-444): 1.39e-124: 370: 74.50
+	Hs
		907132 PSMD1_HUMAN (11-939): 0: 1140: 43.04		PRS8_HUMAN (67-443): 7.97e-122: 362: 44.76
+	Sp
		251840 RPN2_SCHPO (1-965): 0: 1153: 100.00		PRS6B_SCHPO (68-438): 6.66e-109: 328: 48.66
+	Hs
		700 A0A087WW66_HUMAN (11-939): 0: 1052: 40.85		PRS8_HUMAN (67-443): 7.97e-122: 362: 44.76
+	Dm
		820502 PSMD1_DROME (12-939): 0: 1029: 41.21		PRS4_DROME (8-444): 2.11e-125: 372: 73.52
+	Hs
		875247 PSMD1_HUMAN (11-939): 0: 1140: 43.04		TERA_HUMAN (172-442): 7.22e-78: 259: 37.15
+	Dm
		1359001 PSMD1_DROME (12-939): 0: 1029: 41.21		Q9V405_DROME (41-442): 8.51e-124: 367: 48.76
+	Dm
		1359019 PSMD1_DROME (12-939): 0: 1029: 41.21		Q9W414_DROME (58-446): 1.1e-121: 361: 39.23
+	Dm
		1358999 PSMD1_DROME (12-939): 0: 1029: 41.21		Q9V3V6_DROME (80-437): 6.54e-100: 306: 44.06
+	Sc
		693337 RPN2_YEAST (12-964): 0: 969: 40.92		PRS10_YEAST (1-441): 1.24e-122: 365: 35.75
+	Sc
		693270 RPN2_YEAST (12-964): 0: 969: 40.92		PRS6B_YEAST (67-438): 1.82e-112: 339: 49.33
+	Sc
		693349 RPN2_YEAST (12-964): 0: 969: 40.92		PRS8_YEAST (73-439): 3.26e-101: 309: 46.65
+	Hs
		913340 PSMD1_HUMAN (11-939): 0: 1140: 43.04		PRS10_HUMAN (8-146): 5.52e-09: 59.8: 10.49
+	Hs
		701 A0A087WW66_HUMAN (11-939): 0: 1052: 40.85		PRS10_HUMAN (8-146): 5.52e-09: 59.8: 10.49
+	Dm
		186132 PSMD1_DROME (12-939): 0: 1029: 41.21		PRS8_DROME (1-167): 2.6e-11: 67.1: 8.67
+	Sc
		693312 RPN2_YEAST (12-964): 0: 969: 40.92		PRS4_YEAST (8-143): 7.94e-10: 62.5: 7.91