Protein: CATS
Cathepsin S (EC 3.4.22.27)

Gene: CATS, CTSS
Organism: Homo sapiens
Interactions: 135
UniProt ID: P25774

Gene Ontology (top 5):
GO:0001968 - fibronectin binding
GO:0002224 - toll-like receptor signaling pathway
GO:0002250 - adaptive immune response
GO:0002577 - regulation of antigen processing and presentation
GO:0004197 - cysteine-type endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

680666

CATS
Cathepsin S

1

6

High-throughput

0.665

High

680668

CYTD
Cystatin-D

1

13

Small-scale

0.647

High

460770

CATB
Cathepsin B

1

8

High-throughput

0.618

High

680753

CATZ
Cathepsin Z

1

8

High-throughput

0.618

High

571558

IRF2
Interferon regulatory factor 2

3

3

Small-scale

0.609

High

224625

ACTN4
Alpha-actinin-4

1

4

High-throughput

0.515

High

229652

CALU
Calumenin

1

3

High-throughput

0.515

High

251859

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

3

High-throughput

0.515

High

270313

WDR1
WD repeat-containing protein 1

1

1

High-throughput

0.515

High

299938

CBPD
Carboxypeptidase D

1

2

High-throughput

0.515

High

409269

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.515

High

555608

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.515

High

566555

PDIA4
Protein disulfide-isomerase A4

1

8

High-throughput

0.515

High

566914

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.515

High

573335

ENPL
Endoplasmin

1

2

High-throughput

0.515

High

608827

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.515

High

680667

CALR
Calreticulin

1

6

High-throughput

0.515

High

680671

PDIA3
Protein disulfide-isomerase A3

1

9

High-throughput

0.515

High

680675

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.515

High

680680

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.515

High

680683

SERPH
Serpin H1

1

4

High-throughput

0.515

High

680684

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.515

High

680693

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

3

High-throughput

0.515

High

680698

PRDX4
Peroxiredoxin-4

1

1

High-throughput

0.515

High

680699

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.515

High

680704

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.515

High

680706

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.515

High

680712

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.515

High

680723

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.515

High

680754

DJB11
DnaJ homolog subfamily B member 11

1

4

High-throughput

0.515

High

680764

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.515

High

680669

SPB3
Serpin B3

1

2

Small-scale

0.501

High

680672

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.493

High

680685

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.493

High

680691

NUCB2
Nucleobindin-2

1

0

High-throughput

0.493

High

680736

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.493

High

680761

MINP1
Multiple inositol polyphosphate phosphatase 1

1

0

High-throughput

0.493

High

123590

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.479

High

680695

COEA1
Collagen alpha-1(XIV) chain

1

1

High-throughput

0.479

High

680702

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

6

High-throughput

0.479

High

680705

SYK
Lysine--tRNA ligase

1

2

High-throughput

0.479

High

680713

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.479

High

680718

CREL2
Protein disulfide isomerase CRELD2

1

2

High-throughput

0.479

High

680733

MYDGF
Myeloid-derived growth factor

1

1

High-throughput

0.479

High

680742

ERP44
Endoplasmic reticulum resident protein 44

1

9

High-throughput

0.479

High

227800

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.470

High

321182

ERLN2
Erlin-2

1

4

High-throughput

0.470

High

346862

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.470

High

413225

P53
Cellular tumor antigen p53

1

1

High-throughput

0.470

High

417265

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

4

High-throughput

0.470

High

417953

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.470

High

680670

ERP29
Endoplasmic reticulum resident protein 29

1

9

High-throughput

0.470

High

680673

PHB1
Prohibitin 1

1

2

High-throughput

0.470

High

680678

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.470

High

680681

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.470

High

680686

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.470

High

680688

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.470

High

680690

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.470

High

680694

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

7

High-throughput

0.470

High

680696

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.470

High

680707

RCN1
Reticulocalbin-1

1

3

High-throughput

0.470

High

680716

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.470

High

680724

DJC10
DnaJ homolog subfamily C member 10

1

10

High-throughput

0.470

High

680725

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.470

High

680727

GT251
Procollagen galactosyltransferase 1

1

3

High-throughput

0.470

High

680729

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.470

High

680731

IPO4
Importin-4

1

1

High-throughput

0.470

High

680735

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

1

High-throughput

0.470

High

680741

AIF1L
Allograft inflammatory factor 1-like

1

3

High-throughput

0.470

High

680747

XPO5
Exportin-5

1

2

High-throughput

0.470

High

680748

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.470

High

680751

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

2

High-throughput

0.470

High

680752

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.470

High

680760

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.470

High

456616

ANXA2
Annexin A2

1

0

Small-scale

0.460

High

320946

SUN1
SUN domain-containing protein 1

1

0

High-throughput

0.458

High

680744

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.458

High

680682

CAMP
Cathelicidin antimicrobial peptide

1

1

Small-scale

0.445

High

170663

CLGN
Calmegin

1

6

High-throughput

0.437

High

174934

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.437

High

179463

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.437

High

220864

XPOT
Exportin-T

1

2

High-throughput

0.437

High

255574

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

2

High-throughput

0.437

High

318266

MYO1D
Unconventional myosin-Id

1

5

High-throughput

0.437

High

350581

TXD12
Thioredoxin domain-containing protein 12

1

1

High-throughput

0.437

High

533880

IRF1
Interferon regulatory factor 1

1

3

Small-scale

0.437

High

655705

TBG1
Tubulin gamma-1 chain

1

1

High-throughput

0.437

High

680674

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.437

High

680676

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.437

High

680677

NAMPT
Nicotinamide phosphoribosyltransferase

1

1

High-throughput

0.437

High

680679

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.437

High

680689

NOMO3
BOS complex subunit NOMO3

1

2

High-throughput

0.437

High

680692

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.437

High

680708

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.437

High

680717

MIC13
MICOS complex subunit MIC13

1

1

High-throughput

0.437

High

680719

TMTC3
Protein O-mannosyl-transferase TMTC3

1

2

High-throughput

0.437

High

680722

YTHD3
YTH domain-containing family protein 3

1

3

High-throughput

0.437

High

680732

MY18A
Unconventional myosin-XVIIIa

1

7

High-throughput

0.437

High

680739

SDF2
Stromal cell-derived factor 2

1

1

High-throughput

0.437

High

680740

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.437

High

680749

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

680750

DJB12
DnaJ homolog subfamily B member 12

1

3

High-throughput

0.437

High

680756

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

5

High-throughput

0.437

High

680757

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.437

High

680765

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.437

High

194643

CLD3
Claudin-3

1

0

Small-scale

0.269

Low

680709

OCLN
Occludin

1

0

Small-scale

0.269

Low

252509

SEP15
Selenoprotein F

1

0

High-throughput

0.269

Low

680687

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.269

Low

680700

OS9
Protein OS-9

1

0

High-throughput

0.269

Low

680703

MESD
LRP chaperone MESD

1

0

High-throughput

0.269

Low

680711

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.269

Low

680714

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.269

Low

680720

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.269

Low

680730

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.269

Low

680734

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.269

Low

680743

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.269

Low

680745

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.269

Low

680755

SE1L1
Protein sel-1 homolog 1

1

0

High-throughput

0.269

Low

680758

RALY
RNA-binding protein Raly

1

0

High-throughput

0.269

Low

680759

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.269

Low

680762

CNPY2
Protein canopy homolog 2

1

0

High-throughput

0.269

Low

219274

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.249

Low

680697

TWF1
Twinfilin-1

1

0

High-throughput

0.249

Low

680701

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.249

Low

680710

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.249

Low

680715

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

680721

PLGT3
Protein O-glucosyltransferase 3

1

0

High-throughput

0.249

Low

680726

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.249

Low

680728

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.249

Low

680737

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.249

Low

680738

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.249

Low

680746

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.249

Low

680763

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025