Protein: PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)

Gene: PLOD1
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q02809

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0005506 - iron ion binding
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137057

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

2

10

High-throughput

0.811

High

251883

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

10

Small-scale

0.799

High

1038844

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

10

Small-scale

0.778

High

485082

ROA1
Heterogeneous nuclear ribonucleoprotein A1

3

3

High-throughput

0.667

High

384138

CO1A1
Collagen alpha-1(I) chain

3

20

Small-scale

0.662

High

1038963

COLQ
Acetylcholinesterase collagenic tail peptide

3

20

High-throughput

0.662

High

384312

CO4A1

2

20

High-throughput

0.628

High

471586

CO4A2

2

20

High-throughput

0.628

High

551782

CO6A1

2

20

High-throughput

0.628

High

551855

CO6A2

2

20

High-throughput

0.628

High

635450

CO5A1

2

20

High-throughput

0.628

High

712096

CO4A5

2

20

High-throughput

0.628

High

810599

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

20

High-throughput

0.628

High

1038845

COEA1
Collagen alpha-1(XIV) chain

2

20

High-throughput

0.628

High

1038858

CO4A6

2

20

High-throughput

0.628

High

1038900

P3H3
Prolyl 3-hydroxylase 3

2

3

High-throughput

0.628

High

1038920

SC65
Endoplasmic reticulum protein SC65

2

3

High-throughput

0.628

High

384249

CO2A1
Collagen alpha-1(II) chain

2

20

High-throughput

0.621

High

729232

HNRH1
Heterogeneous nuclear ribonucleoprotein H

3

6

High-throughput

0.616

High

937720

FOXA1
Hepatocyte nuclear factor 3-alpha

3

1

High-throughput

0.616

High

938705

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

3

6

High-throughput

0.613

High

1038855

CUL3
Cullin-3

2

7

High-throughput

0.611

High

1038934

COPA1
Collagen alpha-1(XXV) chain

2

20

High-throughput

0.611

High

1038949

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

2

0

High-throughput

0.602

High

1038952

FBX6
F-box only protein 6

3

6

High-throughput

0.599

High

371810

MYC
Myc proto-oncogene protein

3

4

High-throughput

0.585

High

136079

PLK4
Serine/threonine-protein kinase PLK4

2

1

High-throughput

0.574

High

245916

KIF1B
Kinesin-like protein KIF1B

2

4

High-throughput

0.574

High

1038879

PRC2B
Protein PRRC2B

2

1

High-throughput

0.574

High

1038898

KI18B
Kinesin-like protein KIF18B

2

2

High-throughput

0.574

High

1038901

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

1

High-throughput

0.574

High

1038942

ZN106
Zinc finger protein 106

2

1

High-throughput

0.574

High

1038965

RBM7
RNA-binding protein 7

2

1

High-throughput

0.574

High

987555

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

697849

CALR
Calreticulin

1

8

High-throughput

0.536

High

698595

CALX
Calnexin

1

8

High-throughput

0.536

High

717443

PDIA3
Protein disulfide-isomerase A3

1

7

Small-scale

0.536

High

920922

CO4A4

1

20

High-throughput

0.536

High

1038846

COGA1

1

20

High-throughput

0.536

High

1038852

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

High-throughput

0.536

High

1038856

CUL4B
Cullin-4B

1

7

High-throughput

0.536

High

1038859

CO9A3

1

20

High-throughput

0.536

High

1038882

CODA1
Collagen alpha-1(XIII) chain

1

20

High-throughput

0.536

High

1038885

SCAR3
Scavenger receptor class A member 3

1

20

High-throughput

0.536

High

1038895

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1038897

CONA1

1

20

High-throughput

0.536

High

1038929

COLA1

1

20

High-throughput

0.536

High

1038930

COCA1

1

20

High-throughput

0.536

High

1038933

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.536

High

1038961

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

4

High-throughput

0.536

High

176605

KIF3B
Kinesin-like protein KIF3B

1

2

High-throughput

0.515

High

680693

CATS
Cathepsin S

1

3

High-throughput

0.515

High

1038889

WDFY4
WD repeat- and FYVE domain-containing protein 4

1

2

High-throughput

0.515

High

591605

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

1038890

ARHGI
Rho guanine nucleotide exchange factor 18

1

0

High-throughput

0.513

High

439705

INSR
Insulin receptor

1

9

High-throughput

0.500

High

132465

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.489

High

287687

KS6A5
Ribosomal protein S6 kinase alpha-5

1

1

High-throughput

0.489

High

909538

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.489

High

1038853

CUL1
Cullin-1

1

7

High-throughput

0.489

High

1038854

CUL2
Cullin-2

1

7

High-throughput

0.489

High

1038864

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.489

High

1038907

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.489

High

1038922

CUL5
Cullin-5

1

7

High-throughput

0.489

High

1038941

GAN
Gigaxonin

1

1

High-throughput

0.489

High

1038962

TAOK2
Serine/threonine-protein kinase TAO2

1

2

High-throughput

0.489

High

218077

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

229695

CALU
Calumenin

1

3

High-throughput

0.479

High

241446

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

345691

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

363156

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

400685

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

534954

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

537006

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

566640

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

651285

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

692933

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

766466

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

876671

HSP13
Heat shock 70 kDa protein 13

1

4

High-throughput

0.479

High

951106

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

961970

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1015378

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.479

High

1038849

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1038851

DNJC3
DnaJ homolog subfamily C member 3

1

14

High-throughput

0.479

High

1038861

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

1038872

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

3

High-throughput

0.479

High

1038873

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

4

High-throughput

0.479

High

1038874

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1038875

TECT1
Tectonic-1

1

5

High-throughput

0.479

High

1038887

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1038902

DJC10
DnaJ homolog subfamily C member 10

1

14

High-throughput

0.479

High

1038909

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.479

High

1038911

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1038912

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

1038923

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

1038926

CALR3
Calreticulin-3

1

8

High-throughput

0.479

High

1038939

DJC25
DnaJ homolog subfamily C member 25

1

10

High-throughput

0.479

High

1038943

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1038955

DJB12
DnaJ homolog subfamily B member 12

1

9

High-throughput

0.479

High

1038957

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.479

High

1038958

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.479

High

131970

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

272090

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

418076

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

904618

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1038867

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.458

High

1038906

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

1038928

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1038964

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

465492

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.457

High

952117

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.445

High

1038847

SLC31
Amino acid transporter heavy chain SLC3A1

1

1

High-throughput

0.445

High

1038881

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1038917

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

1038937

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

157260

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

247837

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

315483

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

335100

ARI2
E3 ubiquitin-protein ligase ARIH2

1

4

High-throughput

0.437

High

406083

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

411767

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

425454

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.437

High

472663

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.437

High

588505

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

635262

EFNA1
Ephrin-A1

1

6

High-throughput

0.437

High

695255

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767997

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

914192

EFNA3
Ephrin-A3

1

6

High-throughput

0.437

High

928422

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.437

High

962715

RND3
Rho-related GTP-binding protein RhoE

1

4

High-throughput

0.437

High

970362

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1038860

GRB7
Growth factor receptor-bound protein 7

1

1

Small-scale

0.437

High

1038862

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

1038863

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.437

High

1038865

TERF2
Telomeric repeat-binding factor 2

1

3

High-throughput

0.437

High

1038868

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1038869

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1038880

EPHAA
Ephrin type-A receptor 10

1

9

High-throughput

0.437

High

1038883

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

1038884

FTM
Protein fantom

1

3

High-throughput

0.437

High

1038886

TECT3
Tectonic-3

1

5

High-throughput

0.437

High

1038888

SYNE3
Nesprin-3

1

3

High-throughput

0.437

High

1038891

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1038915

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

1038919

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

3

High-throughput

0.437

High

1038927

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

12

High-throughput

0.437

High

1038931

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

1

High-throughput

0.437

High

1038940

ATG5
Autophagy protein 5

1

2

High-throughput

0.437

High

1038945

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1038947

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

1038950

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

1038951

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.437

High

1038954

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

1038960

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1038938

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

71633

A8MWQ5
Collagen type XXV alpha 1 chain

1

20

High-throughput

0.407

High

327956

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

6

High-throughput

0.407

High

332211

UCP5
Brain mitochondrial carrier protein 1

1

1

High-throughput

0.407

High

653263

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

765414

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.407

High

911556

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.407

High

1038877

KLH22
Kelch-like protein 22

1

3

High-throughput

0.407

High

1038936

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

1038944

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.407

High

175653

SR140
U2 snRNP-associated SURP motif-containing protein

2

0

High-throughput

0.328

High

275968

DUS11
RNA/RNP complex-1-interacting phosphatase

2

0

High-throughput

0.328

High

340872

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

0

High-throughput

0.328

High

1038878

ODFP2
Outer dense fiber protein 2

2

0

High-throughput

0.328

High

1038892

KDM3B
Lysine-specific demethylase 3B

2

0

High-throughput

0.328

High

1038893

PBIR2
PABIR family member 2

2

0

High-throughput

0.328

High

1038896

MEX3D
RNA-binding protein MEX3D

2

0

High-throughput

0.328

High

1038903

CI040
Uncharacterized protein C9orf40

2

0

High-throughput

0.328

High

1038953

LATS2
Serine/threonine-protein kinase LATS2

2

0

High-throughput

0.318

High

1038866

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

1038870

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.279

Low

1038910

DCLK2
Serine/threonine-protein kinase DCLK2

1

0

High-throughput

0.279

Low

1038916

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

1038921

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.279

Low

1038924

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.279

Low

1038925

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.279

Low

1038932

ZBED2
Zinc finger BED domain-containing protein 2

1

0

High-throughput

0.279

Low

1038905

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.269

Low

1038850

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.251

Low

194149

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

289979

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.249

Low

326695

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.249

Low

861127

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

878986

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1004464

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1038857

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.249

Low

1038871

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1038876

LARP7
La-related protein 7

1

0

High-throughput

0.249

Low

1038894

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1038899

SL9A9
Sodium/hydrogen exchanger 9

1

0

Small-scale

0.249

Low

1038904

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

1038908

NIN
Ninein

1

0

High-throughput

0.249

Low

1038913

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1038918

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1038946

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

1038948

MYO10
Unconventional myosin-X

1

0

Small-scale

0.249

Low

1038956

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1038959

ZO2
Tight junction protein 2

1

0

High-throughput

0.249

Low

1038848

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.232

Low

1038914

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.232

Low

1038935

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025