Protein: PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]

Gene: PLOD3
Organism: Homo sapiens
Interactions: 165
UniProt ID: O60568

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001886 - endothelial cell morphogenesis
GO:0005506 - iron ion binding
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

251883

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

10

Small-scale

0.799

High

137015

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

2

10

High-throughput

0.776

High

251833

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

10

Small-scale

0.755

High

251951

EHMT2
Histone-lysine N-methyltransferase EHMT2

6

2

Small-scale

0.672

High

251888

CUL3
Cullin-3

3

7

High-throughput

0.656

High

251839

ESR1
Estrogen receptor

3

1

High-throughput

0.624

High

251983

COHA1
Collagen alpha-1(XVII) chain

2

20

High-throughput

0.606

High

251837

CO4A1

2

20

High-throughput

0.601

High

251847

CO4A2

2

20

High-throughput

0.601

High

251851

CO6A1

2

20

High-throughput

0.601

High

251852

CO6A2

2

20

High-throughput

0.601

High

251867

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

20

High-throughput

0.601

High

251891

CO9A2

2

20

High-throughput

0.601

High

251912

CODA1
Collagen alpha-1(XIII) chain

2

20

High-throughput

0.601

High

251937

GT251
Procollagen galactosyltransferase 1

2

10

High-throughput

0.601

High

251954

COLA1

2

20

High-throughput

0.601

High

251957

COCA1

2

20

High-throughput

0.601

High

251961

C1QT1
Complement C1q tumor necrosis factor-related protein 1

2

20

High-throughput

0.601

High

251981

FBX2
F-box only protein 2

2

6

High-throughput

0.601

High

251984

COLQ
Acetylcholinesterase collagenic tail peptide

2

20

High-throughput

0.601

High

251971

FBX6
F-box only protein 6

3

6

High-throughput

0.599

High

251919

CRIP3
Cysteine-rich protein 3

2

0

High-throughput

0.580

High

251864

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

6

High-throughput

0.574

High

251872

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

2

6

High-throughput

0.574

High

251841

P53
Cellular tumor antigen p53

2

2

Small-scale

0.571

High

250183

VINEX
Vinexin

2

1

High-throughput

0.553

High

73750

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

2

20

High-throughput

0.549

High

251908

KLH22
Kelch-like protein 22

2

3

High-throughput

0.549

High

251838

C1QA
Complement C1q subcomponent subunit A

1

20

High-throughput

0.536

High

251846

MMP2
72 kDa type IV collagenase

1

2

High-throughput

0.536

High

251853

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

251857

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.536

High

251862

PML
Protein PML

1

1

High-throughput

0.536

High

251874

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.536

High

251879

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

20

High-throughput

0.536

High

251884

COGA1

1

20

High-throughput

0.536

High

251889

CO4A6

1

20

High-throughput

0.536

High

251890

CO9A3

1

20

High-throughput

0.536

High

251914

SCAR3
Scavenger receptor class A member 3

1

20

High-throughput

0.536

High

251929

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

251930

CONA1

1

20

High-throughput

0.536

High

251934

GT252
Procollagen galactosyltransferase 2

1

10

High-throughput

0.536

High

251959

COL11
Collectin-11

1

20

High-throughput

0.536

High

251960

C1QT6
Complement C1q tumor necrosis factor-related protein 6

1

20

High-throughput

0.536

High

251964

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.536

High

251968

SPE39
Spermatogenesis-defective protein 39 homolog

1

1

High-throughput

0.536

High

251986

COL10
Collectin-10

1

20

High-throughput

0.536

High

251958

RHXF2
Rhox homeobox family member 2

1

1

High-throughput

0.532

High

251859

CATS
Cathepsin S

1

3

High-throughput

0.515

High

251977

MARCO
Macrophage receptor MARCO

1

20

High-throughput

0.515

High

251886

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

251923

RHOU
Rho-related GTP-binding protein RhoU

1

6

High-throughput

0.501

High

251906

MBRL
Membralin

1

0

High-throughput

0.493

High

251835

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.489

High

251897

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.489

High

251910

PRC2B
Protein PRRC2B

1

1

High-throughput

0.489

High

251915

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

1

High-throughput

0.489

High

251918

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

1

High-throughput

0.489

High

251950

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

2

High-throughput

0.489

High

217585

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

229597

CALU
Calumenin

1

3

High-throughput

0.479

High

240231

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

251844

CATL1
Procathepsin L

1

3

High-throughput

0.479

High

251845

CATB
Cathepsin B

1

5

High-throughput

0.479

High

251848

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

High-throughput

0.479

High

251850

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

251854

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

251860

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

251861

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

251868

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.479

High

251876

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

251880

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

251887

DNJC3
DnaJ homolog subfamily C member 3

1

14

High-throughput

0.479

High

251894

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

251901

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

3

High-throughput

0.479

High

251902

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

4

High-throughput

0.479

High

251904

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

251920

SYNE3
Nesprin-3

1

3

High-throughput

0.479

High

251932

DJC10
DnaJ homolog subfamily C member 10

1

14

High-throughput

0.479

High

251936

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

251945

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

251952

CALR3
Calreticulin-3

1

8

High-throughput

0.479

High

251963

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

251973

DJB12
DnaJ homolog subfamily B member 12

1

9

High-throughput

0.479

High

251974

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.479

High

251975

DNJB9
DnaJ homolog subfamily B member 9

1

9

High-throughput

0.479

High

251976

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.479

High

59215

A2ABF9
[histone H3]-lysine(9) N-methyltransferase

1

2

High-throughput

0.470

High

251907

Q53GL6
RNA binding protein

1

1

High-throughput

0.470

High

251877

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.458

High

251928

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.458

High

251966

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

251836

CO1A1
Collagen alpha-1(I) chain

1

20

Small-scale

0.445

High

251856

CO5A1

1

20

High-throughput

0.445

High

251878

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.445

High

251882

CO7A1
Collagen alpha-1(VII) chain

1

20

High-throughput

0.445

High

251931

P3H3
Prolyl 3-hydroxylase 3

1

3

High-throughput

0.445

High

251939

COMA1

1

20

High-throughput

0.445

High

251944

SC65
Endoplasmic reticulum protein SC65

1

3

High-throughput

0.445

High

251962

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

251982

RALY
RNA-binding protein Raly

1

1

High-throughput

0.439

High

247546

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

251840

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

251842

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.437

High

251855

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

251871

EFNA4
Ephrin-A4

1

6

High-throughput

0.437

High

251875

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.437

High

251885

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.437

High

251892

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.437

High

251895

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

251896

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.437

High

251900

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

251911

EPHAA
Ephrin type-A receptor 10

1

9

High-throughput

0.437

High

251916

TECT3
Tectonic-3

1

5

High-throughput

0.437

High

251922

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

251933

YAF2
YY1-associated factor 2

1

1

High-throughput

0.437

High

251938

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

251940

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

251946

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

251947

AURKB
Aurora kinase B

1

1

High-throughput

0.437

High

251948

TECT2
Tectonic-2

1

5

High-throughput

0.437

High

251953

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

12

High-throughput

0.437

High

251967

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.437

High

251969

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

251972

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

251978

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

251941

PXDN
Peroxidasin homolog

1

0

High-throughput

0.426

High

251834

UCP5
Brain mitochondrial carrier protein 1

1

1

High-throughput

0.407

High

251849

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

20

High-throughput

0.407

High

251965

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.407

High

251909

EFHC2
EF-hand domain-containing family member C2

6

0

High-throughput

0.386

High

251955

RAB3I
Rab-3A-interacting protein

4

0

High-throughput

0.370

High

175493

KHNYN
Protein KHNYN

2

0

High-throughput

0.316

High

251866

COIL
Coilin

2

0

High-throughput

0.316

High

251898

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.316

High

251921

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

251924

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

251949

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

0

High-throughput

0.316

High

251979

IP6K2
Inositol hexakisphosphate kinase 2

2

0

High-throughput

0.316

High

251970

ANLN
Anillin

2

0

High-throughput

0.305

High

251899

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

251926

DPPA2
Developmental pluripotency-associated protein 2

1

0

High-throughput

0.282

High

251870

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.279

Low

251881

RBM6
RNA-binding protein 6

1

0

High-throughput

0.279

Low

251903

GEN
Flap endonuclease GEN homolog 1

1

0

High-throughput

0.279

Low

251905

FWCH1
FLYWCH-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

251925

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

High-throughput

0.279

Low

251927

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

251935

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.279

Low

251942

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.279

Low

238836

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.269

Low

251980

F153A
Protein FAM153A

1

0

High-throughput

0.251

Low

251843

NFM
Neurofilament medium polypeptide

1

0

High-throughput

0.249

Low

251858

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

251863

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.249

Low

251865

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

251869

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.249

Low

251893

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

251943

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.249

Low

251873

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.232

Low

251913

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

251917

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

251956

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

251985

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025