HitPredict

Interactor 1: RHP23 (O74803)
UV excision repair protein rhp23 (RAD23 homolog)
Gene: RHP23

Interactor 2: DSK2 (Q10169)
Deubiquitination-protection protein dph1
Gene: dph1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11788722
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UBA~UBA, UBA~ubiquitin, ubiquitin~ubiquitin, UBA~XPC-binding
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding GO:0036503 - ERAD pathway GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 368 Sp			1 354
+	Hs
		872124 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		RD23A_HUMAN (3-352): 8.51e-57: 190: 14.68
+	Hs
		872123 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		RD23A_HUMAN (3-352): 8.51e-57: 190: 14.68
+	Hs
		872301 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		UBL7_HUMAN (23-348): 1.11e-48: 169: 20.58
+	Hs
		872241 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		RD23B_HUMAN (4-351): 1.14e-47: 167: 16.54
+	Hs
		872275 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		DDI2_HUMAN (4-268): 6.01e-43: 155: 15.52
+	Hs
		872201 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		UBL7_HUMAN (23-348): 1.11e-48: 169: 20.58
+	Sc
		697098 RAD23_YEAST (1-363): 4.47e-80: 252: 34.41		DSK2_YEAST (3-352): 3.76e-55: 186: 38.65
+	Hs
		474969 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		UBB_HUMAN (4-147): 1.89e-39: 141: 16.99
+	Hs
		872317 RD23B_HUMAN (1-365): 1.65e-94: 289: 31.84		UBQL2_HUMAN (4-296): 9.42e-34: 133: 17.55
+	Sc
		697061 RAD23_YEAST (1-363): 4.47e-80: 252: 34.41		RAD23_YEAST (4-353): 1.24e-47: 167: 14.75
+	Hs
		872226 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		UBQL2_HUMAN (4-296): 9.42e-34: 133: 17.55
+	Hs
		872229 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		UBQL1_HUMAN (4-295): 2.6e-33: 131: 19.46
+	Hs
		872136 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		RS27A_HUMAN (4-91): 1.4e-31: 118: 23.86
+	Hs
		872222 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		UBQL4_HUMAN (4-317): 1.38e-28: 118: 16.95
+	Hs
		872137 RD23A_HUMAN (1-365): 8.95e-88: 270: 33.25		RL40_HUMAN (4-76): 1.09e-13: 69.2: 28.77
+	Dm
		547941 Q9V3W9_DROME (1-327): 9.47e-65: 213: 32.65		RS27A_DROME (4-91): 5.38e-32: 119: 23.86
+	Dm
		1362833 Q9VCD5_DROME (1-366): 5.62e-59: 194: 25.82		Q9VWD9_DROME (4-299): 7.91e-31: 124: 18.86
+	Dm
		547946 Q9VCD5_DROME (1-366): 5.62e-59: 194: 25.82		RS27A_DROME (4-91): 5.38e-32: 119: 23.86
+	Dm
		574854 Q9VCD5_DROME (1-366): 5.62e-59: 194: 25.82		RL40_DROME (4-76): 1.09e-13: 69.2: 28.77