HitPredict

Interactor 1: LIRA1 (O75019)
Leukocyte immunoglobulin-like receptor subfamily A member 1 (CD85 antigen-like family member I) (Leukocyte immunoglobulin-like receptor 6) (LIR-6) (CD antigen CD85i)
Gene: LILRA1

Interactor 2: LIRA3 (Q8N6C8)
Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
Gene: LILRA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ig_2~Ig_2, Ig_2~Ig_3
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0032396 - inhibitory MHC class I receptor activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 489 Hs			1 439
+	Hs
		1161634 LIRA6_HUMAN (1-488): 5.64e-114: 346: 66.39		U5XH19_HUMAN (1-438): 2.79e-104: 319: 66.44
+	Hs
		1235888 U5XH19_HUMAN (1-488): 3.63e-111: 339: 67.21		LIRA3_HUMAN (1-439): 3.37e-106: 323: 100.00
+	Hs
		252781 LIRA6_HUMAN (1-488): 5.64e-114: 346: 66.39		LIRB3_HUMAN (1-428): 2.43e-98: 309: 66.36
+	Hs
		87574 U5XH19_HUMAN (1-488): 3.63e-111: 339: 67.21		C9JWL8_HUMAN (1-428): 2.04e-99: 311: 67.52
+	Hs
		1232784 LIRB2_HUMAN (1-465): 1.31e-99: 313: 78.28		LIRA3_HUMAN (1-439): 3.37e-106: 323: 100.00
+	Hs
		1235887 LIRB1_HUMAN (1-452): 6.41e-98: 310: 79.87		LIRA3_HUMAN (1-439): 3.37e-106: 323: 100.00
+	Hs
		1336275 ROBO1_HUMAN (17-466): 7.54e-76: 261: 11.37		ROBO2_HUMAN (1-437): 6.56e-69: 239: 14.54
+	Hs
		798235 KI3L1_HUMAN (1-334): 5.17e-68: 226: 37.39		KI3S1_HUMAN (1-334): 1.12e-67: 221: 35.91
+	Hs
		1378225 ROBO1_HUMAN (17-466): 7.54e-76: 261: 11.37		ROBO1_HUMAN (119-438): 8.08e-47: 175: 14.33
+	Rn
		222935 ROBO1_RAT (17-476): 2.76e-75: 260: 11.09		DCC_RAT (30-435): 8.75e-36: 142: 11.97
+	Hs
		1232785 LIRB2_HUMAN (1-465): 1.31e-99: 313: 78.28		LIRB4_HUMAN (317-429): 4.22e-16: 82.1: 30.09
+	Hs
		798230 KI3L1_HUMAN (1-334): 5.17e-68: 226: 37.39		KI2S2_HUMAN (319-439): 1.07e-24: 105: 38.53
+	Hs
		798163 KI3L1_HUMAN (1-334): 5.17e-68: 226: 37.39		KI2L2_HUMAN (319-439): 6.28e-23: 100: 37.71
+	Hs
		798136 KI3L1_HUMAN (1-334): 5.17e-68: 226: 37.39		KI2L1_HUMAN (319-439): 2.78e-22: 99.1: 38.53
+	Hs
		47501 A0A8I5QEB2_HUMAN (1-344): 6.67e-66: 219: 36.60		KI2S5_HUMAN (319-439): 1.93e-24: 104: 39.34
+	Hs
		798168 KI3S1_HUMAN (1-334): 8.72e-67: 221: 36.50		KI2L2_HUMAN (319-439): 6.28e-23: 100: 37.71