HitPredict

Interactor 1: DEPD5 (O75140)
GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)
Gene: DEPDC5

Interactor 2: NPRL2 (Q8WTW4)
GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)
Gene: NPRL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 28199306, 25263562, 28199315, 23723238, 25936802, 28514442, 33961781, 25366275
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains IML1~NPR2
Common GO terms GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0010508 - positive regulation of autophagy
GO:0032007 - negative regulation of TOR signaling
GO:0034198 - cellular response to amino acid starvation
and 2 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 1603
Hs

1 380
+ Sp
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024