Protein: MGME1
Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)

Gene: MGME1
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q9BQP7

Gene Ontology (top 5):
GO:0000002 - mitochondrial genome maintenance
GO:0005739 - mitochondrion
GO:0006264 - mitochondrial DNA replication
GO:0008297 - single-stranded DNA exodeoxyribonuclease activity
GO:0043504 - mitochondrial DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1309210

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

4

0

High-throughput

0.670

High

729228

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

1309763

RM46
Large ribosomal subunit protein mL46

3

0

High-throughput

0.638

High

867360

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

972572

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

2

0

High-throughput

0.602

High

1306461

MIPEP
Mitochondrial intermediate peptidase

2

0

High-throughput

0.602

High

1309767

TRI45
E3 ubiquitin-protein ligase TRIM45

2

1

High-throughput

0.574

High

262938

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1086752

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1309776

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

1

High-throughput

0.536

High

452866

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

616660

GCSH
Glycine cleavage system H protein, mitochondrial

1

0

High-throughput

0.513

High

682446

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

790270

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

947136

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.513

High

1159922

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1309758

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1309759

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1309775

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1309781

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

1309783

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

1309784

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

878719

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.489

High

440695

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

959020

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1018020

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

59278

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

374775

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

486622

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

500054

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

777701

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789948

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799338

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

827549

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

981396

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

990273

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1014472

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

1020537

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1045840

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1051061

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1068058

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1124800

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

1128231

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1152946

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1184006

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

1282805

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1286837

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1289101

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1301117

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1309760

TR61B
tRNA

1

0

High-throughput

0.458

High

1309761

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1309762

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1309766

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1309769

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1309770

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1309771

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

1309782

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

69730

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.407

High

274376

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

0

High-throughput

0.328

High

1201002

LUZP1
Leucine zipper protein 1

2

0

High-throughput

0.328

High

1223442

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.328

High

1309777

CBLC
E3 ubiquitin-protein ligase CBL-C

2

0

High-throughput

0.328

High

1309768

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

796339

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.282

High

158224

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.279

Low

270212

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.279

Low

450670

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

815192

NPTX2
Neuronal pentraxin-2

1

0

High-throughput

0.279

Low

877858

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.279

Low

941365

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.279

Low

945331

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1016670

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.279

Low

1025685

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.279

Low

1057373

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.279

Low

1082947

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.279

Low

1138775

ZN691
Zinc finger protein 691

1

0

High-throughput

0.279

Low

1153729

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1201145

THOC4
THO complex subunit 4

1

0

High-throughput

0.279

Low

1231058

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.279

Low

1235182

CB073
Uncharacterized protein C2orf73

1

0

High-throughput

0.279

Low

1235624

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1238583

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.279

Low

1254787

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.279

Low

1282095

RAB24
Ras-related protein Rab-24

1

0

High-throughput

0.279

Low

1285630

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1294444

AJUBA
LIM domain-containing protein ajuba

1

0

High-throughput

0.279

Low

1307472

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.279

Low

1309764

TCAL2
Transcription elongation factor A protein-like 2

1

0

High-throughput

0.279

Low

1309773

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

1309778

SOX13
Transcription factor SOX-13

1

0

High-throughput

0.279

Low

1309779

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

1309780

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.279

Low

1309785

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1219562

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.269

Low

1309774

DCDC2
Doublecortin domain-containing protein 2

1

0

High-throughput

0.268

Low

173096

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.249

Low

553560

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

570015

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

868310

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

986980

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.249

Low

1171446

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1172826

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.249

Low

1291104

CDCA5
Sororin

1

0

High-throughput

0.249

Low

1309765

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

1309772

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024