HitPredict

Interactor 1: ICOSL (O75144)
ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
Gene: ICOSLG

Interactor 2: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Gal-bind_lectin~V-set
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 302 Hs			1 135
+	Hs
		449287 CD276_HUMAN (7-255): 1.46e-45: 163: 24.10		LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00
+	Hs
		572440 PD1L2_HUMAN (12-294): 2.42e-36: 133: 18.66		LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47
+	Hs
		121171 CD276_HUMAN (7-255): 1.46e-45: 163: 24.10		LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13
+	Hs
		119413 CD276_HUMAN (7-255): 1.46e-45: 163: 24.10		LEG9_HUMAN (10-133): 2.96e-35: 126: 31.50
+	Hs
		121172 NR3L1_HUMAN (28-279): 3.69e-39: 144: 18.42		LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13
+	Hs
		119415 NR3L1_HUMAN (28-279): 3.69e-39: 144: 18.42		LEG9_HUMAN (10-133): 2.96e-35: 126: 31.50
+	Hs
		121158 NECT1_HUMAN (14-281): 1.97e-10: 63: 14.59		LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13