HitPredict

Interactor 1: PP6R2 (O75170)
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)
Gene: PPP6R2

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 966 Hs			1 949
+	Hs
		257172 PP6R2_HUMAN (1-966): 0: 893: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		1014025 PP6R3_HUMAN (1-914): 0: 746: 46.31		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		925891 PP6R3_HUMAN (1-914): 0: 746: 46.31		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		926056 PP6R1_HUMAN (1-898): 0: 640: 39.94		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		257152 PP6R2_HUMAN (1-966): 0: 893: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		212577 PP6R2_HUMAN (1-966): 0: 893: 100.00		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		321563 PP6R3_HUMAN (1-914): 0: 746: 46.31		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		302165 PP6R3_HUMAN (1-914): 0: 746: 46.31		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Hs
		203223 SYNJ1_HUMAN (399-965): 5.49e-29: 127: 10.15		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		203219 SYNJ1_HUMAN (399-965): 5.49e-29: 127: 10.15		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		203194 SYNJ1_HUMAN (399-965): 5.49e-29: 127: 10.15		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Rn
		1144064 SYNJ1_RAT (399-965): 1.33e-30: 132: 11.27		Q66HM2_RAT (12-945): 0: 631: 17.92