Protein: PSB4
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)

Gene: PSB4, PSMB4
Organism: Homo sapiens
Interactions: 197
UniProt ID: P28070

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0001530 - lipopolysaccharide binding
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

637632

PSA2
Proteasome subunit alpha type-2

8

19

Small-scale

0.970

High

656520

PSB7
Proteasome subunit beta type-7

6

19

Small-scale

0.946

High

594456

PSB1
Proteasome subunit beta type-1

6

20

High-throughput

0.946

High

656548

POMP
Proteasome maturation protein

5

15

Small-scale

0.927

High

637326

PSA1
Proteasome subunit alpha type-1

5

20

High-throughput

0.922

High

638068

PSA4
Proteasome subunit alpha type-4

5

20

Small-scale

0.922

High

656150

PSA5
Proteasome subunit alpha type-5

5

20

Small-scale

0.922

High

156231

PSA7
Proteasome subunit alpha type-7

5

20

Small-scale

0.919

High

656430

PSB2
Proteasome subunit beta type-2

5

20

Small-scale

0.919

High

637776

PSA3
Proteasome subunit alpha type-3

4

20

High-throughput

0.910

High

656417

PSB5
Proteasome subunit beta type-5

4

20

Small-scale

0.902

High

656429

PSB3
Proteasome subunit beta type-3

4

19

Small-scale

0.897

High

656451

PSME1
Proteasome activator complex subunit 1

4

20

High-throughput

0.895

High

656463

PSME4
Proteasome activator complex subunit 4

4

12

High-throughput

0.895

High

656439

PSA6
Proteasome subunit alpha type-6

4

20

Small-scale

0.892

High

656091

PSB9
Proteasome subunit beta type-9

3

20

High-throughput

0.861

High

656416

PSB6
Proteasome subunit beta type-6

3

20

High-throughput

0.861

High

656505

PSMA8
Proteasome subunit alpha-type 8

3

20

High-throughput

0.861

High

656542

PSME2
Proteasome activator complex subunit 2

3

20

High-throughput

0.861

High

121690

PSD11
26S proteasome non-ATPase regulatory subunit 11

3

20

High-throughput

0.847

High

656442

PRS8
26S proteasome regulatory subunit 8

3

20

Small-scale

0.827

High

656036

PSB8
Proteasome subunit beta type-8

2

20

Small-scale

0.793

High

656423

PSB10
Proteasome subunit beta type-10

2

19

Small-scale

0.793

High

656470

SMAD1
Mothers against decapentaplegic homolog 1

6

1

Small-scale

0.733

High

656550

FBX7
F-box only protein 7

5

7

Small-scale

0.714

High

656444

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.691

High

656556

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

20

Small-scale

0.683

High

130755

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

20

Small-scale

0.676

High

656508

PSMF1
Proteasome inhibitor PI31 subunit

3

7

High-throughput

0.667

High

656513

PSMG2
Proteasome assembly chaperone 2

3

13

High-throughput

0.667

High

656449

UBE3A
Ubiquitin-protein ligase E3A

3

20

Small-scale

0.640

High

656544

PRP19
Pre-mRNA-processing factor 19

2

6

Small-scale

0.631

High

314737

PSMG1
Proteasome assembly chaperone 1

2

6

High-throughput

0.628

High

572864

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

656422

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.618

High

656426

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.618

High

656441

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.618

High

656458

CUL1
Cullin-1

2

8

Small-scale

0.614

High

198551

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

11

High-throughput

0.611

High

345994

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.611

High

528599

CFTR
Cystic fibrosis transmembrane conductance regulator

2

7

High-throughput

0.611

High

159896

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

4

High-throughput

0.606

High

260289

PROP1
Homeobox protein prophet of Pit-1

2

2

High-throughput

0.606

High

656452

TLE5
TLE family member 5

2

1

High-throughput

0.606

High

656472

PKN1
Serine/threonine-protein kinase N1

2

3

High-throughput

0.606

High

656476

CCD57
Coiled-coil domain-containing protein 57

2

2

High-throughput

0.606

High

656522

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

656524

PITX2
Pituitary homeobox 2

2

1

High-throughput

0.606

High

656529

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

7

High-throughput

0.606

High

226591

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.601

High

171480

UBD
Ubiquitin D

2

20

Small-scale

0.595

High

656455

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

20

Small-scale

0.595

High

656487

Q6IBT1
Proteasome subunit beta

1

19

High-throughput

0.590

High

121943

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

20

High-throughput

0.584

High

656427

YAP1
Transcriptional coactivator YAP1

2

9

High-throughput

0.584

High

656437

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

14

High-throughput

0.584

High

656546

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

15

High-throughput

0.584

High

656418

GRAN
Grancalcin

2

0

High-throughput

0.580

High

656425

BCL6
B-cell lymphoma 6 protein

2

0

High-throughput

0.580

High

656477

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.580

High

656481

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.580

High

656485

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

656495

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.580

High

656498

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

656518

TEKT5
Tektin-5

2

0

High-throughput

0.580

High

656530

SYP2L
Synaptopodin 2-like protein

2

0

High-throughput

0.580

High

656533

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

656536

SPG21
Maspardin

2

0

High-throughput

0.580

High

656537

CNOT2
CCR4-NOT transcription complex subunit 2

2

0

High-throughput

0.580

High

656557

HEMK1
MTRF1L release factor glutamine methyltransferase

2

0

High-throughput

0.580

High

656519

CRBN
Protein cereblon

1

1

Small-scale

0.573

High

50895

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

17

High-throughput

0.573

High

656445

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.547

High

566295

KPCA
Protein kinase C alpha type

1

2

High-throughput

0.541

High

656446

SKP1
S-phase kinase-associated protein 1

1

9

High-throughput

0.536

High

656457

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

8

High-throughput

0.536

High

656474

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.536

High

656496

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.536

High

656527

FOXP3
Forkhead box protein P3

1

2

High-throughput

0.536

High

656532

NRBP2
Nuclear receptor-binding protein 2

1

5

High-throughput

0.536

High

656541

AMFR
E3 ubiquitin-protein ligase AMFR

1

18

High-throughput

0.536

High

656551

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

8

High-throughput

0.536

High

656558

STK24
Serine/threonine-protein kinase 24

1

8

High-throughput

0.536

High

656448

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

656516

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

656432

ATX1
Ataxin-1

1

3

High-throughput

0.515

High

656454

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.515

High

656549

RNF11
RING finger protein 11

1

19

High-throughput

0.515

High

555305

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

656501

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.513

High

656547

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

394162

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

316799

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.500

High

656523

FEV
Protein FEV

1

3

High-throughput

0.500

High

656526

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.500

High

656540

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.500

High

506293

MBL2
Mannose-binding protein C

1

4

High-throughput

0.489

High

656447

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

656467

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

656468

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.489

High

656499

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.489

High

386148

P53
Cellular tumor antigen p53

1

0

High-throughput

0.479

High

175643

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

Small-scale

0.479

High

243975

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

255529

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

282539

RNF8
E3 ubiquitin-protein ligase RNF8

1

9

High-throughput

0.479

High

294404

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

298185

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

304790

MFN2
Mitofusin-2

1

7

High-throughput

0.479

High

319727

HERC2
E3 ubiquitin-protein ligase HERC2

1

6

High-throughput

0.479

High

324242

BAG3
BAG family molecular chaperone regulator 3

1

7

High-throughput

0.479

High

349898

RASK
GTPase KRas

1

2

High-throughput

0.479

High

354305

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

6

High-throughput

0.479

High

397798

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

487154

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

488132

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.479

High

503491

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

552005

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

569236

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

570482

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

9

High-throughput

0.479

High

607591

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.479

High

656419

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

656420

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

656421

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

4

Small-scale

0.479

High

656424

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

656428

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.479

High

656431

ATX3
Ataxin-3

1

4

High-throughput

0.479

High

656434

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

12

High-throughput

0.479

High

656435

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

656436

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

656438

SEM1
26S proteasome complex subunit SEM1

1

5

Small-scale

0.479

High

656440

UBC12
NEDD8-conjugating enzyme Ubc12

1

12

High-throughput

0.479

High

656443

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

12

High-throughput

0.479

High

656450

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

9

High-throughput

0.479

High

656453

DUS4
Dual specificity protein phosphatase 4

1

2

High-throughput

0.479

High

656456

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

656460

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

High-throughput

0.479

High

656464

CUL7
Cullin-7

1

4

High-throughput

0.479

High

656465

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

20

High-throughput

0.479

High

656466

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

14

High-throughput

0.479

High

656469

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.479

High

656471

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

11

High-throughput

0.479

High

656473

FSCN1
Fascin

1

1

High-throughput

0.479

High

656475

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

656478

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

656479

MIDN
Midnolin

1

7

High-throughput

0.479

High

656480

AKIR2
Akirin-2

1

11

Small-scale

0.479

High

656483

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

656484

TET5C
Terminal nucleotidyltransferase 5C

1

4

High-throughput

0.479

High

656486

VIR
Protein virilizer homolog

1

7

High-throughput

0.479

High

656490

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

3

High-throughput

0.479

High

656492

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

656493

MOB3C
MOB kinase activator 3C

1

6

High-throughput

0.479

High

656497

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

656500

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.479

High

656502

NHLC2
NHL repeat-containing protein 2

1

5

High-throughput

0.479

High

656504

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

656510

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

20

High-throughput

0.479

High

656511

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

656512

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

656515

OPTN
Optineurin

1

3

High-throughput

0.479

High

656517

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

7

Small-scale

0.479

High

656521

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

656528

PIP30
PSME3-interacting protein

1

4

High-throughput

0.479

High

656538

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

656539

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

656543

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

656545

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

656552

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

7

Small-scale

0.479

High

656553

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

656554

TRAF6
TNF receptor-associated factor 6

1

7

High-throughput

0.479

High

656433

OAZ1
Ornithine decarboxylase antizyme 1

1

0

Small-scale

0.460

High

122151

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.458

High

453168

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.458

High

602223

CD9
CD9 antigen

1

0

High-throughput

0.458

High

656488

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

656509

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

656534

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.458

High

656555

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.458

High

656525

PSMG3
Proteasome assembly chaperone 3

1

7

Small-scale

0.457

High

435547

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.457

High

401467

JUN
Transcription factor Jun

1

15

High-throughput

0.445

High

496367

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

656459

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

656482

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

656531

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

329393

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

656461

GRM2
Metabotropic glutamate receptor 2

1

7

High-throughput

0.437

High

656489

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

656507

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

656535

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.437

High

656491

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

656503

MOT11
Monocarboxylate transporter 11

1

6

High-throughput

0.407

High

656494

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.316

High

656506

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

656462

PDIA5
Protein disulfide-isomerase A5

1

0

High-throughput

0.279

Low

656514

CC74A
Coiled-coil domain-containing protein 74A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024