HitPredict

Interactor 1: LIPA2 (O75334)
Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)
Gene: PPFIA2

Interactor 2: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PDZ~SAM_1
Common GO terms	GO:0005829 - cytosol GO:0042734 - presynaptic membrane GO:0048786 - presynaptic active zone GO:2000300 - regulation of synaptic vesicle exocytosis
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 1692
+	Hs
		255248 LIPA3_HUMAN (1-1257): 1.49e-110: 377: 55.59		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		1025310 LIPA1_HUMAN (1-1257): 6.82e-109: 372: 62.89		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		724903 MYH9_HUMAN (1-629): 2.88e-25: 116: 12.71		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		725194 MYH10_HUMAN (3-517): 9.54e-21: 101: 12.41		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		1200039 MRCKB_HUMAN (4-315): 1.39e-11: 71.4: 12.65		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Dm
		114424 M9PCD4_DROME (1-1182): 6.32e-99: 345: 42.56		Q9VEE5_DROME (300-867): 6.29e-19: 96.1: 16.12
+	Dm
		114422 M9PCD4_DROME (1-1182): 6.32e-99: 345: 42.56		Q9V483_DROME (1458-1669): 3.3e-11: 70.8: 16.74
+	Hs
		128818 MYH9_HUMAN (1-629): 2.88e-25: 116: 12.71		P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48
+	Hs
		128891 MY18A_HUMAN (41-596): 1.41e-23: 110: 16.28		P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48
+	Hs
		1309697 MYH4_HUMAN (493-1048): 5.04e-15: 82.9: 9.25		SYT3_HUMAN (744-864): 1.76e-09: 64.7: 36.29