HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: EIF3A (Q14152)
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)
Gene: EIF3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31239290, 32416067, 39358380
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 1382
+	Hs
		259536 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		MYH10_HUMAN (16-1091): 5.14e-43: 174: 10.13
+	Hs
		259627 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		YLPM1_HUMAN (774-1359): 6.65e-43: 174: 21.91
+	Hs
		259535 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		MYH9_HUMAN (72-1154): 3.11e-41: 168: 8.84
+	Hs
		1121888 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		EIF3A_HUMAN (1-1382): 1e-125: 425: 100.00
+	Hs
		260124 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		MYH14_HUMAN (461-1365): 9.31e-32: 137: 11.66
+	Hs
		259978 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		PLEC_HUMAN (497-1343): 1.74e-18: 94.5: 13.97
+	Hs
		260085 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		NIPBL_HUMAN (599-1299): 2.7e-11: 71.1: 13.13
+	Sc
		796622 GCN5_YEAST (140-462): 2.78e-42: 163: 14.41		EIF3A_YEAST (7-889): 2e-75: 273: 23.50
+	At
		1409033 GCN5_ARATH (139-455): 3.05e-31: 132: 17.11		EIF3A_ARATH (3-851): 2.19e-75: 273: 34.34
+	Hs
		773034 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		MYH9_HUMAN (72-1154): 3.11e-41: 168: 8.84
+	Hs
		342097 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		MYH6_HUMAN (126-1225): 1.08e-38: 160: 9.29
+	Hs
		1141173 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		NIPBL_HUMAN (599-1299): 2.7e-11: 71.1: 13.13
+	Hs
		342153 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		MAP1A_HUMAN (494-1117): 2.9e-30: 133: 13.68