Protein: EIF3A
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 110 kDa subunit homolog) (eIF3 p110) (Translation initiation factor eIF3, p110 subunit homolog)

Gene: EIF3A, RPG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 174
UniProt ID: P38249

Gene Ontology (top 5):
GO:0000131 - incipient cellular bud site
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002188 - translation reinitiation
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738372

EIF3C
Eukaryotic translation initiation factor 3 subunit C

16

5

Small-scale

0.986

High

438421

EIF3B
Eukaryotic translation initiation factor 3 subunit B

19

7

Small-scale

0.768

High

796584

EIF3I
Eukaryotic translation initiation factor 3 subunit I

12

15

Small-scale

0.756

High

796625

EIF3G
Eukaryotic translation initiation factor 3 subunit G

12

4

Small-scale

0.756

High

796563

IF5
Eukaryotic translation initiation factor 5

7

5

Small-scale

0.746

High

748163

SUI1
Eukaryotic translation initiation factor eIF-1

7

2

Small-scale

0.744

High

796627

EIF3J
Eukaryotic translation initiation factor 3 subunit J

9

0

Small-scale

0.722

High

737710

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

5

4

Small-scale

0.709

High

747323

RSSA1
Small ribosomal subunit protein uS2A

4

2

Small-scale

0.698

High

632885

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

4

1

Small-scale

0.694

High

523741

HSP71
Heat shock protein SSA1

4

10

High-throughput

0.666

High

478612

IF2B
Eukaryotic translation initiation factor 2 subunit beta

3

2

Small-scale

0.662

High

796571

CSK2C
Casein kinase II subunit beta'

3

3

Small-scale

0.662

High

796620

RLI1
Translation initiation factor RLI1

3

4

Small-scale

0.662

High

579281

HSC82
ATP-dependent molecular chaperone HSC82

3

8

High-throughput

0.643

High

670617

SIS1
Protein SIS1

3

2

High-throughput

0.643

High

674582

RS2
Small ribosomal subunit protein uS5

3

1

Small-scale

0.640

High

796576

IF2P
Eukaryotic translation initiation factor 5B

3

1

Small-scale

0.640

High

435044

RS3
Small ribosomal subunit protein uS3

3

0

Small-scale

0.619

High

435922

RS13
Small ribosomal subunit protein uS15

2

1

High-throughput

0.611

High

796595

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.611

High

796648

IF6
Eukaryotic translation initiation factor 6

2

1

High-throughput

0.601

High

706917

TF2B
Transcription initiation factor IIB

3

1

High-throughput

0.587

High

149724

RS9A
Small ribosomal subunit protein uS4A

2

0

High-throughput

0.585

High

403489

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

1

Small-scale

0.584

High

464588

PBS2
MAP kinase kinase PBS2

2

20

High-throughput

0.584

High

792007

GBLP
Small ribosomal subunit protein RACK1

2

15

Small-scale

0.584

High

796565

OTU2
OTU domain-containing protein 2

2

1

Small-scale

0.584

High

751848

SLA2
Protein SLA2

1

20

Small-scale

0.573

High

392631

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.571

High

510429

HSP77
Import motor subunit, mitochondrial

2

14

High-throughput

0.571

High

553606

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.563

High

796643

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.563

High

486149

TBA1
Tubulin alpha-1 chain

1

2

Small-scale

0.561

High

757320

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

Small-scale

0.559

High

689414

RS7A
Small ribosomal subunit protein eS7A

2

1

High-throughput

0.558

High

753330

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.553

High

544640

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.552

High

622936

CSK22
Casein kinase II subunit alpha'

2

20

Small-scale

0.549

High

726972

HS104
Heat shock protein 104

2

0

High-throughput

0.547

High

626709

HSP60
Heat shock protein 60, mitochondrial

2

5

High-throughput

0.537

High

542962

CDC24
Cell division control protein 24

1

17

High-throughput

0.536

High

721884

XPO1
Exportin-1

1

5

High-throughput

0.536

High

796587

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.536

High

796608

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

796614

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

10

High-throughput

0.536

High

796650

DUF1
DUB-associated factor 1

1

15

High-throughput

0.536

High

796596

RSSA2
Small ribosomal subunit protein uS2B

2

2

Small-scale

0.521

High

383666

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.517

High

726140

2AAA
Protein phosphatase PP2A regulatory subunit A

1

1

High-throughput

0.515

High

632082

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.513

High

602424

PHO85
Cyclin-dependent protein kinase PHO85

1

14

Small-scale

0.501

High

796628

POC1
Proteasome chaperone 1

1

0

High-throughput

0.493

High

796634

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.493

High

721605

RENT1
ATP-dependent helicase NAM7

1

2

Small-scale

0.481

High

796572

END3
Actin cytoskeleton-regulatory complex protein END3

1

15

High-throughput

0.481

High

796585

TBP6
Probable 26S proteasome subunit YTA6

1

10

High-throughput

0.481

High

796644

GYP5
GTPase-activating protein GYP5

1

2

High-throughput

0.481

High

667028

PCL1
PHO85 cyclin-1

1

0

Small-scale

0.480

High

364493

CDK1
Cyclin-dependent kinase 1

1

12

High-throughput

0.479

High

430836

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

436390

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.479

High

441871

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

444499

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.479

High

571348

CPYI
Carboxypeptidase Y inhibitor

1

1

Small-scale

0.479

High

641427

RCC1
Guanine nucleotide exchange factor SRM1

1

2

High-throughput

0.479

High

646382

RAD53
Serine/threonine-protein kinase RAD53

1

7

High-throughput

0.479

High

737838

HOG1
Mitogen-activated protein kinase HOG1

1

15

High-throughput

0.479

High

795307

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

796142

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

796564

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

796570

IF1A
Eukaryotic translation initiation factor 1A

1

1

High-throughput

0.479

High

796574

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.479

High

796577

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

10

Small-scale

0.479

High

796578

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

9

Small-scale

0.479

High

796581

ARB1
ABC transporter ATP-binding protein ARB1

1

2

Small-scale

0.479

High

796604

CDH1
APC/C activator protein CDH1

1

15

Small-scale

0.479

High

796605

EIF2A
Eukaryotic translation initiation factor 2A

1

7

High-throughput

0.479

High

796609

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

796621

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

796638

NEW1
[NU+] prion formation protein 1

1

2

High-throughput

0.479

High

796642

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

747120

RT04
Small ribosomal subunit protein uS2m

1

2

High-throughput

0.470

High

777228

OSH1
Oxysterol-binding protein homolog 1

1

1

High-throughput

0.470

High

796603

MLC1
Myosin light chain 1

1

11

High-throughput

0.470

High

796647

OSH2
Oxysterol-binding protein homolog 2

1

1

High-throughput

0.470

High

796580

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.460

High

796597

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.460

High

796633

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

512063

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

514605

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

558690

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

645397

XRN1
5'-3' exoribonuclease 1

1

0

Small-scale

0.458

High

657080

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

Small-scale

0.458

High

689015

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

747818

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

751386

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

778289

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782158

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

796561

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

796566

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

796568

SDO1L
Restriction of telomere capping protein 3

1

0

Small-scale

0.458

High

796586

TM108
Protein TMA108

1

0

High-throughput

0.458

High

796588

CSN11
Cop9 signalosome complex subunit 11

1

0

Small-scale

0.458

High

796591

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

796599

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

796601

PSP2
Protein PSP2

1

0

High-throughput

0.458

High

796606

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

796615

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

796618

ESP1
Separin

1

0

High-throughput

0.458

High

796619

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.458

High

796624

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

796635

SGO1
Shugoshin

1

0

High-throughput

0.458

High

796639

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

796645

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

386683

TBB
Tubulin beta chain

1

2

High-throughput

0.445

High

481601

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

526520

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

675947

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

741451

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

742833

HSP79
Heat shock protein homolog SSE2

1

13

High-throughput

0.445

High

763427

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.445

High

796567

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

796579

HSP7E
Heat shock protein SSC3, mitochondrial

1

14

High-throughput

0.445

High

796582

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

796583

RIO2
Serine/threonine-protein kinase RIO2

1

3

Small-scale

0.445

High

796610

JJJ1
J protein JJJ1

1

4

High-throughput

0.445

High

410087

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

512403

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

585917

CSK21
Casein kinase II subunit alpha

1

18

Small-scale

0.437

High

679606

CDC48
Cell division control protein 48

1

10

High-throughput

0.437

High

779213

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.437

High

796573

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.437

High

796589

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.437

High

796593

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

12

High-throughput

0.437

High

796602

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

796607

COPA
Coatomer subunit alpha

1

8

High-throughput

0.437

High

796612

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

796616

ULP1
Ubiquitin-like-specific protease 1

1

3

High-throughput

0.437

High

796622

GCN5
Histone acetyltransferase GCN5

1

15

High-throughput

0.437

High

796626

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

796636

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.437

High

796637

AP3D
AP-3 complex subunit delta

1

14

High-throughput

0.437

High

796646

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

796649

SMC6
Structural maintenance of chromosomes protein 6

1

13

High-throughput

0.437

High

453559

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

737597

GSH1
Glutamate--cysteine ligase

1

0

High-throughput

0.426

High

796562

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

8

High-throughput

0.407

High

796594

ERJ5
ER-localized J domain-containing protein 5

1

4

High-throughput

0.407

High

796613

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.307

High

796641

MED2
Mediator of RNA polymerase II transcription subunit 2

2

0

High-throughput

0.307

High

796575

LAA1
AP-1 accessory protein LAA1

2

0

High-throughput

0.306

High

512969

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.305

High

455024

RS19A
Small ribosomal subunit protein eS19A

2

0

High-throughput

0.298

High

781295

AUR1
Inositol phosphorylceramide synthase catalytic subunit AUR1

1

0

High-throughput

0.269

Low

796629

RRG8
Required for respiratory growth protein 8, mitochondrial

1

0

High-throughput

0.269

Low

796617

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

796623

RCF1
Respiratory supercomplex factor 1, mitochondrial

1

0

High-throughput

0.251

Low

796640

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

433602

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

503005

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504175

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

511656

RS23B
Small ribosomal subunit protein uS12B

1

0

Small-scale

0.249

Low

796560

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

796590

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

796592

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

796598

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

796600

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

796630

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

796631

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

796632

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

796651

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

796569

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.232

Low

796611

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025