HitPredict

Interactor 1: VPS4B (O75351)
Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)
Gene: VPS4B

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0044877 - protein-containing complex binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 618
+	Hs
		1036199 VPS4A_HUMAN (4-443): 2.68e-130: 384: 80.23		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		913257 PRS10_HUMAN (4-386): 2.98e-96: 296: 26.46		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		913246 PRS10_HUMAN (4-386): 2.98e-96: 296: 26.46		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		874832 TERA_HUMAN (75-429): 2.87e-77: 258: 28.89		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Dm
		1097055 TERA_DROME (115-429): 3.18e-76: 255: 28.13		DIAP1_DROME (35-174): 2.28e-22: 102: 23.57
+	Hs
		875158 TERA_HUMAN (75-429): 2.87e-77: 258: 28.89		RFFL_HUMAN (567-618): 2.51e-17: 85.8: 42.31