Protein: TRIPC
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)

Gene: TRIPC, TRIP12
Organism: Homo sapiens
Interactions: 217
UniProt ID: Q14669

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906667

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.946

High

995959

UB2L3
Ubiquitin-conjugating enzyme E2 L3

5

20

Small-scale

0.919

High

507976

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

20

Small-scale

0.882

High

842760

CDN2A
Cyclin-dependent kinase inhibitor 2A

5

12

Small-scale

0.720

High

1129354

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

5

18

Small-scale

0.711

High

372030

MYC
Myc proto-oncogene protein

4

12

Small-scale

0.709

High

158440

RFXK
DNA-binding protein RFXANK

1

14

High-throughput

0.691

High

1129398

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.691

High

291651

XRP2
Protein XRP2

3

1

High-throughput

0.667

High

904715

MECP2
Methyl-CpG-binding protein 2

3

4

High-throughput

0.667

High

931188

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

1

High-throughput

0.667

High

1102831

EIF3I
Eukaryotic translation initiation factor 3 subunit I

3

17

High-throughput

0.667

High

982188

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

487314

PARP1
Poly [ADP-ribose] polymerase 1

2

14

Small-scale

0.634

High

1129356

FBXW7
F-box/WD repeat-containing protein 7

2

12

Small-scale

0.634

High

457093

CAN1
Calpain-1 catalytic subunit

2

11

High-throughput

0.628

High

1129351

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

4

High-throughput

0.628

High

259948

BRD4
Bromodomain-containing protein 4

2

14

Small-scale

0.624

High

168534

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.618

High

241687

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

1129391

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

High-throughput

0.618

High

907428

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

11

High-throughput

0.611

High

990223

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1115652

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

18

High-throughput

0.611

High

1129318

IF16
Gamma-interferon-inducible protein 16

2

2

High-throughput

0.611

High

558130

XRCC6
X-ray repair cross-complementing protein 6

2

10

High-throughput

0.601

High

588698

RFA2
Replication protein A 32 kDa subunit

2

6

High-throughput

0.584

High

695460

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.584

High

768194

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

979654

H4
Histone H4

2

5

High-throughput

0.584

High

980768

H2B1C
Histone H2B type 1-C/E/F/G/I

2

15

High-throughput

0.584

High

998316

H31
Histone H3.1

2

7

High-throughput

0.584

High

1129317

EZH2
Histone-lysine N-methyltransferase EZH2

2

7

Small-scale

0.584

High

1129388

ZRAN1
Ubiquitin thioesterase ZRANB1

2

12

High-throughput

0.584

High

1129343

ARF
Tumor suppressor ARF

1

2

Small-scale

0.578

High

1129312

OPCM
Opioid-binding protein/cell adhesion molecule

2

3

High-throughput

0.574

High

776192

SOX6
Transcription factor SOX-6

1

15

Small-scale

0.573

High

1129332

PTF1A
Pancreas transcription factor 1 subunit alpha

1

3

Small-scale

0.573

High

402368

GBA1
Lysosomal acid glucosylceramidase

1

2

Small-scale

0.561

High

1106536

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.561

High

1110835

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

7

Small-scale

0.561

High

873958

NRIP1
Nuclear receptor-interacting protein 1

1

2

High-throughput

0.541

High

1091609

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.537

High

1101210

NMI
N-myc-interactor

1

0

Small-scale

0.537

High

74485

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

15

High-throughput

0.536

High

179045

IMA6
Importin subunit alpha-6

1

11

High-throughput

0.536

High

253630

IMA7
Importin subunit alpha-7

1

11

High-throughput

0.536

High

286985

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

20

High-throughput

0.536

High

396113

ESR1
Estrogen receptor

1

20

High-throughput

0.536

High

563769

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

572718

AK1A1
Aldo-keto reductase family 1 member A1

1

2

High-throughput

0.536

High

636853

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.536

High

785168

RL4
Large ribosomal subunit protein uL4

1

5

High-throughput

0.536

High

822666

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.536

High

911245

IMA5
Importin subunit alpha-5

1

11

High-throughput

0.536

High

975692

RL7A
Large ribosomal subunit protein eL8

1

16

High-throughput

0.536

High

984628

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.536

High

985659

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

1013053

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

1

High-throughput

0.536

High

1037150

H11
Histone H1.1

1

9

High-throughput

0.536

High

1054463

EXOS9
Exosome complex component RRP45

1

8

High-throughput

0.536

High

1060980

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.536

High

1089656

ILF3
Interleukin enhancer-binding factor 3

1

15

High-throughput

0.536

High

1110976

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1112017

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

1129311

NUMA1
Nuclear mitotic apparatus protein 1

1

11

High-throughput

0.536

High

1129315

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.536

High

1129319

H2B2E
Histone H2B type 2-E

1

15

High-throughput

0.536

High

1129340

RN168
E3 ubiquitin-protein ligase RNF168

1

2

Small-scale

0.536

High

1129347

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

17

High-throughput

0.536

High

1129358

EFMT3
EEF1A lysine methyltransferase 3

1

8

High-throughput

0.536

High

1129369

NPAS1
Neuronal PAS domain-containing protein 1

1

9

High-throughput

0.536

High

1129370

H2AJ
Histone H2A.J

1

10

High-throughput

0.536

High

1129373

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1129375

TOLIP
Toll-interacting protein

1

4

High-throughput

0.536

High

1129377

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

1129389

CYH4
Cytohesin-4

1

2

High-throughput

0.536

High

1129392

TPX2
Targeting protein for Xklp2

1

4

High-throughput

0.536

High

1129393

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1129396

PHF8
Histone lysine demethylase PHF8

1

12

High-throughput

0.536

High

1129364

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

1039217

RL6
Large ribosomal subunit protein eL6

1

5

High-throughput

0.515

High

158653

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.513

High

298171

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

1129324

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

1129338

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1129353

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

181888

SMAD9
Mothers against decapentaplegic homolog 9

1

20

High-throughput

0.508

High

323991

CSTN1
Calsyntenin-1

1

10

Small-scale

0.508

High

185699

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

16

High-throughput

0.501

High

326956

UBE4B
Ubiquitin conjugation factor E4 B

1

3

Small-scale

0.501

High

540863

ERG
Transcriptional regulator ERG

1

5

Small-scale

0.501

High

1006402

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.501

High

1112837

CUL2
Cullin-2

1

12

Small-scale

0.501

High

447016

NPM
Nucleophosmin

1

4

Small-scale

0.500

High

351778

LGI1
Leucine-rich glioma-inactivated protein 1

1

2

High-throughput

0.489

High

657235

KALM
Anosmin-1

1

2

High-throughput

0.489

High

1012694

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.489

High

1129349

OR6T1
Olfactory receptor 6T1

1

3

High-throughput

0.489

High

1129352

JPH3
Junctophilin-3

1

6

High-throughput

0.489

High

1129360

CERS2
Ceramide synthase 2

1

3

High-throughput

0.489

High

1129367

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

1129368

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.489

High

1129374

DNAI2
Dynein axonemal intermediate chain 2

1

15

High-throughput

0.489

High

1129397

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.489

High

64187

CRNS1
Carnosine synthase 1

1

0

Small-scale

0.486

High

129076

MEN1
Menin

1

1

High-throughput

0.479

High

157377

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.479

High

190907

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

272173

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

285278

EED
Polycomb protein EED

1

19

High-throughput

0.479

High

345818

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

375522

RASK
GTPase KRas

1

10

High-throughput

0.479

High

400837

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

18

High-throughput

0.479

High

418984

H2A1B
Histone H2A type 1-B/E

1

10

High-throughput

0.479

High

595771

H13
Histone H1.3

1

9

High-throughput

0.479

High

675500

TYY1
Transcriptional repressor protein YY1

1

10

Small-scale

0.479

High

687411

PTBP1
Polypyrimidine tract-binding protein 1

1

12

Small-scale

0.479

High

691004

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

697113

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

729836

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730586

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

754843

H2B1B
Histone H2B type 1-B

1

15

High-throughput

0.479

High

791384

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

810100

RL3
Large ribosomal subunit protein uL3

1

7

High-throughput

0.479

High

830735

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

858656

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.479

High

872326

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

879088

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

883537

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

891550

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.479

High

897810

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.479

High

934614

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.479

High

964281

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.479

High

966313

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971527

1433E
14-3-3 protein epsilon

1

14

High-throughput

0.479

High

1016859

H33
Histone H3.3

1

7

High-throughput

0.479

High

1045284

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1049290

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1052017

CALD1
Caldesmon

1

16

High-throughput

0.479

High

1083356

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

8

High-throughput

0.479

High

1097294

CBX3
Chromobox protein homolog 3

1

13

High-throughput

0.479

High

1099895

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

1129309

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

Small-scale

0.479

High

1129310

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

High-throughput

0.479

High

1129313

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1129314

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

1129316

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

Small-scale

0.479

High

1129322

RN123
E3 ubiquitin-protein ligase RNF123

1

20

High-throughput

0.479

High

1129323

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.479

High

1129330

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1129333

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1129334

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1129336

SERC5
Serine incorporator 5

1

2

Small-scale

0.479

High

1129337

TAXB1
Tax1-binding protein 1

1

17

High-throughput

0.479

High

1129339

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1129342

SIR6
NAD-dependent protein deacylase sirtuin-6

1

11

High-throughput

0.479

High

1129344

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1129348

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1129350

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1129355

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

15

Small-scale

0.479

High

1129357

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1129371

GNL3
Guanine nucleotide-binding protein-like 3

1

7

Small-scale

0.479

High

1129372

RBM4
RNA-binding protein 4

1

15

Small-scale

0.479

High

1129376

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1129379

ECT2
Protein ECT2

1

11

Small-scale

0.479

High

1129380

WDR76
WD repeat-containing protein 76

1

17

High-throughput

0.479

High

1129382

ANLN
Anillin

1

2

High-throughput

0.479

High

1129383

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.479

High

1129385

PIHD1
PIH1 domain-containing protein 1

1

3

Small-scale

0.479

High

1129386

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1129395

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

1129400

TLN1
Talin-1

1

18

Small-scale

0.479

High

1129321

OCAD2
OCIA domain-containing protein 2

1

1

High-throughput

0.470

High

869740

MTR1A
Melatonin receptor type 1A

1

6

High-throughput

0.464

High

880920

MTR1B
Melatonin receptor type 1B

1

6

High-throughput

0.464

High

247906

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

915443

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

1129331

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1129335

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1129341

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

1129346

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1129359

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1129365

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1129399

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1129327

MCAF1
Activating transcription factor 7-interacting protein 1

1

9

High-throughput

0.457

High

1129384

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

47522

RPSA2
Small ribosomal subunit protein uS2B

1

9

High-throughput

0.445

High

191645

MAGB2
Melanoma-associated antigen B2

1

16

High-throughput

0.445

High

231573

PRKY
Putative serine/threonine-protein kinase PRKY

1

20

High-throughput

0.445

High

429892

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

601671

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.445

High

1129381

E41L5
Band 4.1-like protein 5

1

14

High-throughput

0.445

High

1129390

AGO1
Protein argonaute-1

1

1

High-throughput

0.445

High

1129394

AKP8L
A-kinase anchor protein 8-like

1

6

High-throughput

0.445

High

1129363

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

420533

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

5

High-throughput

0.437

High

886270

ARL4D
ADP-ribosylation factor-like protein 4D

1

10

High-throughput

0.437

High

967206

RRAS2
Ras-related protein R-Ras2

1

9

High-throughput

0.437

High

1071154

ARL16
ADP-ribosylation factor-like protein 16

1

10

High-throughput

0.437

High

1126076

GRM2
Metabotropic glutamate receptor 2

1

2

High-throughput

0.437

High

1129320

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

1129325

LMBRL
Protein LMBR1L

1

4

High-throughput

0.437

High

1129326

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

1129328

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

1129378

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

946998

DSCR9
Down syndrome critical region protein 9

1

2

High-throughput

0.417

High

1129387

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

5

Small-scale

0.417

High

516838

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

5

High-throughput

0.407

High

1129345

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High

1129366

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.407

High

1127379

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1129362

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

1129401

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1129402

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

1129329

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

1129361

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025