HitPredict

Interactor 1: PP1RB (O60927)
E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3)
Gene: PPP1R11

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	26496610, 27880917, 27173435, 17353931, 28330616, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Metallophos~PPI_Ypi1, PPI_Ypi1~STPPase_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 327
+	Hs
		261910 PP1RB_HUMAN (1-103): 3.4e-35: 119: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Dm
		873524 Q7JYN8_DROME (3-125): 4.43e-36: 122: 35.34		PP11_DROME (6-327): 0: 567: 85.09
+	Dm
		873633 Q9VRC5_DROME (2-100): 1.07e-34: 121: 38.00		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		261907 PP1RB_HUMAN (1-103): 3.4e-35: 119: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Dm
		873547 Q9VRC5_DROME (2-100): 1.07e-34: 121: 38.00		PP11_DROME (6-327): 0: 567: 85.09
+	Mm
		968162 PP1RB_MOUSE (1-99): 1.56e-29: 105: 84.62		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Mm
		63073 A5A4Y9_MOUSE (1-99): 1.09e-28: 102: 85.58		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Dm
		559077 Q9VMI2_DROME (3-125): 3.91e-36: 122: 35.34		PP12_DROME (6-303): 0: 546: 88.59
+	Dm
		559081 Q9VRC5_DROME (2-100): 1.07e-34: 121: 38.00		PP12_DROME (6-303): 0: 546: 88.59
+	Dm
		1051596 Q9VRC5_DROME (2-100): 1.07e-34: 121: 38.00		PP13_DROME (6-303): 0: 541: 88.93
+	Sp
		153478 YPI1_SCHPO (8-72): 6.44e-21: 82.6: 40.91		PP11_SCHPO (1-327): 0: 564: 80.73
+	At
		873662 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP13_ARATH (8-322): 0: 547: 73.97
+	At
		873663 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP14_ARATH (8-307): 0: 546: 79.00
+	At
		873661 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP12_ARATH (8-304): 0: 537: 78.52
+	At
		873670 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP16_ARATH (8-325): 0: 537: 72.33
+	At
		719401 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP11_ARATH (8-304): 0: 535: 77.93
+	At
		308441 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP17_ARATH (1-317): 0: 525: 74.76
+	At
		873669 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP15_ARATH (8-304): 0: 522: 77.18
+	At
		1342875 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP19_ARATH (8-310): 0: 519: 70.96
+	At
		308447 INH3_ARATH (1-89): 2.77e-24: 91: 32.58		PP18_ARATH (8-304): 0: 518: 71.38