HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	29568343
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 509
+	Mm
		411926 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LCK_MOUSE (1-509): 0: 657: 96.86
+	Hs
		411781 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		269514 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		HCK_HUMAN (1-509): 0: 602: 65.04
+	Mm
		763391 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		FYN_MOUSE (30-507): 0: 586: 58.80
+	Hs
		269511 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		269517 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRC_HUMAN (20-507): 0: 586: 55.00
+	Mm
		639444 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LYN_MOUSE (1-509): 0: 585: 62.33
+	Hs
		269513 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		269512 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		269515 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FGR_HUMAN (1-507): 0: 579: 52.76
+	Hs
		269523 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		BLK_HUMAN (1-509): 0: 557: 59.35
+	Hs
		269519 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FRK_HUMAN (50-503): 0: 530: 48.20
+	Hs
		412249 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		523046 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433867 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		269541 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRMS_HUMAN (29-502): 3.04e-160: 465: 41.34
+	Hs
		411764 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411861 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433831 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433388 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		YES_HUMAN (26-507): 0: 581: 58.06