Protein: RHG05
Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)

Gene: RHG05, ARHGAP5
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q13017

Gene Ontology (top 5):
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962004

RHOA
Transforming protein RhoA

3

20

Small-scale

0.861

High

910032

RND2
Rho-related GTP-binding protein RhoN

2

20

Small-scale

0.815

High

962727

RND3
Rho-related GTP-binding protein RhoE

2

20

Small-scale

0.815

High

1092740

RND1
Rho-related GTP-binding protein Rho6

2

20

Small-scale

0.815

High

977972

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

919922

PLK1
Serine/threonine-protein kinase PLK1

4

9

High-throughput

0.694

High

1092744

SMUF2
E3 ubiquitin-protein ligase SMURF2

3

7

High-throughput

0.674

High

1092732

KAZRN
Kazrin

3

0

High-throughput

0.622

High

126573

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

466230

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

601263

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

953418

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955111

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

988328

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015401

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1092743

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1092745

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1092736

DOCK3
Dedicator of cytokinesis protein 3

2

5

High-throughput

0.594

High

458387

ADRB2
Beta-2 adrenergic receptor

1

2

Small-scale

0.552

High

876676

HSP13
Heat shock 70 kDa protein 13

1

8

High-throughput

0.541

High

286191

CSDE1
Cold shock domain-containing protein E1

1

1

Small-scale

0.501

High

129033

MEN1
Menin

1

2

High-throughput

0.479

High

400749

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

413735

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

446961

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

459567

PROF1
Profilin-1

1

7

High-throughput

0.479

High

487254

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

556052

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

574242

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.479

High

710210

EPHA2
Ephrin type-A receptor 2

1

15

High-throughput

0.479

High

764709

CTNB1
Catenin beta-1

1

10

High-throughput

0.479

High

830649

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

878442

PAXI
Paxillin

1

14

Small-scale

0.479

High

896517

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.479

High

974725

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

High-throughput

0.479

High

1092728

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

1092729

ZYX
Zyxin

1

8

High-throughput

0.479

High

1092730

DOC11
Dedicator of cytokinesis protein 11

1

5

High-throughput

0.479

High

1092731

RN123
E3 ubiquitin-protein ligase RNF123

1

10

High-throughput

0.479

High

1092733

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1092738

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.479

High

1092739

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

1

High-throughput

0.479

High

1092741

KAT6A
Histone acetyltransferase KAT6A

1

4

High-throughput

0.479

High

1092742

GBP3
Guanylate-binding protein 3

1

3

High-throughput

0.479

High

1092746

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1092748

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1092749

FAF1
FAS-associated factor 1

1

2

Small-scale

0.479

High

1037135

H11
Histone H1.1

1

7

High-throughput

0.470

High

1092747

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.458

High

588577

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

695335

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

768071

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

1092735

MGAP
MAX gene-associated protein

1

1

High-throughput

0.437

High

1092734

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

1092737

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025