HitPredict

Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Interactor 2: DKK2 (Q9UBU2)
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
Gene: DKK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 21944579
Identification Methods	affinity chromatography technology, bio-layer interferometry, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016055 - Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1613 Hs			1 259
+	Mm
		222597 LRP6_MOUSE (1-1613): 0: 1791: 97.83		DKK1_MOUSE (12-258): 8.64e-114: 329: 42.80
+	Hs
		270245 LRP6_HUMAN (1-1613): 0: 1791: 100.00		DKK1_HUMAN (15-258): 1.13e-108: 316: 41.60
+	Hs
		258359 LRP5_HUMAN (15-1613): 0: 1642: 69.70		DKK2_HUMAN (1-259): 6.51e-127: 362: 100.00
+	Hs
		258282 LRP5_HUMAN (15-1613): 0: 1642: 69.70		DKK1_HUMAN (15-258): 1.13e-108: 316: 41.60
+	Hs
		258358 LRP5_HUMAN (15-1613): 0: 1642: 69.70		DKK4_HUMAN (78-259): 1.65e-78: 238: 43.55
+	Hs
		1269032 SORL_HUMAN (1169-1391): 5.2e-22: 106: 19.56		DKK2_HUMAN (1-259): 6.51e-127: 362: 100.00
+	Hs
		1349412 LRP1B_HUMAN (1278-1613): 9.86e-11: 69.3: 14.12		DKK2_HUMAN (1-259): 6.51e-127: 362: 100.00
+	Hs
		957657 LRP2_HUMAN (1361-1613): 9.96e-11: 69.3: 8.85		DKK2_HUMAN (1-259): 6.51e-127: 362: 100.00