HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: CREB1 (P16220)
Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
Gene: CREB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	9687510, 11500364, 9873047
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006468 - protein phosphorylation GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 327
+	Hs
		272846 KS6A4_HUMAN (18-786): 0: 727: 59.38		CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00
+	Hs
		556872 KS6A1_HUMAN (4-752): 0: 714: 40.27		CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00
+	Hs
		270370 KS6A5_HUMAN (17-802): 0: 825: 100.00		ATF1_HUMAN (72-326): 2.98e-94: 282: 65.13
+	Hs
		556790 AKT1_HUMAN (375-708): 8.05e-98: 314: 26.14		CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00
+	Hs
		556773 KAPCA_HUMAN (422-737): 2.5e-99: 313: 27.66		CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00