HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10899310
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 1124
+	Hs
		854198 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		JAK3_HUMAN (1-1124): 0: 968: 100.00
+	Hs
		238321 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Mm
		936443 STAM1_MOUSE (1-513): 1.83e-114: 351: 53.96		JAK2_MOUSE (4-1101): 0: 897: 48.38
+	Hs
		238425 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		277005 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		277013 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		TYK2_HUMAN (828-1122): 5.53e-34: 144: 20.62
+	Hs
		272790 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		272786 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		337470 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		411715 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		272788 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		276982 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		433753 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Mm
		936444 STAM1_MOUSE (1-513): 1.83e-114: 351: 53.96		JAK3_MOUSE (802-1118): 2.5e-29: 128: 17.42
+	Hs
		616806 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		339110 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		272785 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		339057 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		338405 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Rn
		88616 D3ZHG8_RAT (1-520): 3.22e-61: 214: 14.75		NTRK1_RAT (500-780): 9.24e-14: 78.2: 24.18